Effect of gamma-ray irradiation on degradation of di(2-ethylhexyl)phthalate in polyvinyl chloride sheet
Effect of gamma-ray irradiation on degradation of di(2-ethylhexyl)phthalate in polyvinyl chloride sheet
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DOI：
10.1016/j.ijpharm.2009.04.019
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发表时间：
2009-07-06
影响因子：
5.8
通讯作者：
Nakazawa, Hiroyuki
中科院分区：
文献类型：
--
作者：
Ito, Rie;Miura, Naoko;Nakazawa, Hiroyuki
邻苯二甲酸二(2-乙基己基)酯(DEHP)从聚氯乙烯(PVC)医疗器械中迁移的风险评估是患者面临的一个重要问题。本研究的目的是确定聚氯乙烯板材中DEHP的降解和迁移。为此，对DEHP及其分解产物邻苯二甲酸单(2-乙基己基)酯(MEHP)和邻苯二甲酸(PA)的同时测定方法进行了改进。测定了它们在0~50kGy伽马射线辐照的聚氯乙烯薄膜中的迁移量。DEHP迁移水平随照射剂量的增加而降低，而MEHP和PA迁移水平随照射剂量的增加而增加。测试了聚氯乙烯板材的硬度和弹性模量，但没有观察到DEHP迁移率与这些参数之间的明显关系。(C)2009爱思唯尔B.V.保留所有权利。
The risk assessment of di(2-ethylhexyl)phthalate (DEHP) migration from polyvinyl chloride (PVC) medical devices is an important issue for patients. The aim of this study was to determine DEHP degradation and migration from PVC sheets. To this end, the method for the simultaneous determination of DEHP and its breakdown products (mono(2-ethylhexyl)phthalate (MEHP) and phthalic acid (PA)) was improved. Their migration levels from 0 to 50 kGy gamma-ray irradiated PVC sheets were determined. DEHP migration level decreased in proportion to the dose of gamma-ray irradiation, while MEHP and PA migration levels increased. The hardness and the elastic modulus of PVC sheets were examined, but no clear relationship between DEHP migration and these parameters was observed. (C) 2009 Elsevier B.V. All rights reserved.