AU-rich elements and associated factors: are there unifying principles?
AU-rich elements and associated factors: are there unifying principles?
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DOI：
10.1093/nar/gki1012
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发表时间：
2005
影响因子：
14.9
通讯作者：
Osborne HB
中科院分区：
文献类型：
--
作者：
Barreau C;Paillard L;Osborne HB
mRNA稳定性的控制是一个重要的过程，它允许细胞不仅限制而且快速调节调节因子的表达，所述调节因子的过度表达可能对宿主生物体有害。多年来，已知富含A和U核苷酸的序列元件或富含AU的元件（战神）靶向mRNA以进行快速降解。在这项调查中，在简要总结了战神的序列特征的数据，我们提出了一个分析已知的ARE结合蛋白（ARE-BP）相对于其mRNA的目标和后果，他们结合的mRNA。在该分析中，考虑了mRNA稳定性的变化和较少研究的对翻译的影响。该分析突出了由一个ARE-BP结合的大量mRNA，并且相反地，与任何特定的含有ARE的mRNA相关联的大量ARE-BP。这种情况下讨论功能冗余或对抗。mRNA的稳定性和翻译之间的潜在关系进行了讨论。最后，我们提出了几个假设，可以统一已发表的数据，并为未来的研究提出了建议。
The control of mRNA stability is an important process that allows cells to not only limit, but also rapidly adjust, the expression of regulatory factors whose over expression may be detrimental to the host organism. Sequence elements rich in A and U nucleotides or AU-rich elements (AREs) have been known for many years to target mRNAs for rapid degradation. In this survey, after briefly summarizing the data on the sequence characteristics of AREs, we present an analysis of the known ARE-binding proteins (ARE-BP) with respect to their mRNA targets and the consequences of their binding to the mRNA. In this analysis, both the changes in mRNA stability and the lesser studied effects on translation are considered. This analysis highlights the multitude of mRNAs bound by one ARE-BP and conversely the large number of ARE-BP that associate with any particular ARE-containing mRNA. This situation is discussed with respect to functional redundancies or antagonisms. The potential relationship between mRNA stability and translation is also discussed. Finally, we present several hypotheses that could unify the published data and suggest avenues for future research.
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影响因子：
9.8
作者：
Antic, D;Keene, JD
通讯作者：
Keene, JD
影响因子：
4.8
作者：
Beckel-Mitchener, AC;Miera, A;Perrone-Bizzozero, NI
通讯作者：
Perrone-Bizzozero, NI
影响因子：
5.3
作者：
BREWER, G;ROSS, J
通讯作者：
ROSS, J
影响因子：
5.3
作者：
CHEN, CYA;CHEN, TM;SHYU, AB
通讯作者：
SHYU, AB
影响因子：
5.3
作者：
BREWER, G
通讯作者：
BREWER, G