Urogenital Schistosomiasis in Women of Reproductive Age in Tanzania's Lake Victoria Region
Urogenital Schistosomiasis in Women of Reproductive Age in Tanzania's Lake Victoria Region
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DOI：
10.4269/ajtmh.2011.10-0585
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发表时间：
2011-03-01
影响因子：
3.3
通讯作者：
Fitzgerald, Daniel W.
中科院分区：
文献类型：
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作者：
Downs, Jennifer A.;Mguta, Charles;Fitzgerald, Daniel W.
我们对居住在坦桑尼亚西北部 8 个乡村的 457 名 18-50 岁女性进行了一项基于社区的研究。女性泌尿生殖道血吸虫病 (FUS) 的总体患病率为 5%，但范围为 0% 至 11%。 FUS 与人类免疫缺陷病毒 (HIV) 感染（比值比 [OR] = 4.0，95% 置信区间 [CI] = 1.2-13.5）和较年轻的年龄相关（与年龄 > 25 岁相比，年龄 < 25 岁的 OR = 5.5 和 95% CI = 1.2-26.3，25-29 岁的 OR = 8.2 和 95% CI = 1.7-38.4） 35 年）。 HIV 总体感染率为 5.9%，但 FUS 女性感染率为 17%。我们观察到血吸虫病存在显着的地理聚集性：靠近维多利亚湖的北部村庄曼氏血吸虫感染较多（P < 0.0001），而距离湖较远的南部村庄则埃及血吸虫感染较多（P = 0.002）。我们的数据支持这样的假设：FUS 可能是 HIV 感染的危险因素，并可能导致撒哈拉以南非洲地区年轻女性的 HIV 感染率极高。
We conducted a community-based study of 457 women aged 18-50 years living in eight rural villages in northwest Tanzania. The prevalence of female urogenital schistosomiasis (FUS) was 5% overall but ranged from 0% to 11%. FUS was associated with human immunodeficiency virus (HIV) infection (odds ratio [OR] = 4.0,95% confidence interval [CI] = 1.2-13.5) and younger age (OR = 5.5 and 95% CI = 1.2-26.3 for ages < 25 years and OR = 8.2 and 95% CI = 1.7-38.4 for ages 25-29 years compared with age > 35 years). Overall HIV prevalence was 5.9% but was 17% among women with FUS. We observed significant geographical clustering of schistosomiasis: northern villages near Lake Victoria had more Schistosoma mansoni infections (P < 0.0001), and southern villages farther from the lake had more S. haematobium (P = 0.002). Our data support the postulate that FUS may be a risk factor for HIV infection and may contribute to the extremely high rates of HIV among young women in sub-Saharan Africa.