Effect of the angiotensin II receptor antagonist losartan on uric acid and oxypurine metabolism in healthy subjects
Effect of the angiotensin II receptor antagonist losartan on uric acid and oxypurine metabolism in healthy subjects
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DOI：
10.2169/internalmedicine.41.793
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发表时间：
2002-10-01
影响因子：
1.2
通讯作者：
Yamamoto, T
中科院分区：
文献类型：
--
作者：
Hamada, T;Hisatome, I;Yamamoto, T
目的观察血管紧张素Ⅱ受体拮抗剂氯沙坦对尿酸和羟嘌呤代谢的急性影响。在氯沙坦给药前和给药后6小时内采集血液和尿液样本，测定尿酸和羟嘌呤。结果氯沙坦可降低血尿酸浓度（从5.9 ± 0.9 mg/dl降至5.2 ± 1.0 mg/dl），提高尿酸清除率，尿酸清除率在2 h后达到最大值，而依那普利无此作用。氯沙坦还诱导次黄嘌呤的血浆浓度增加，在第4小时达到峰值，其尿清除率降低，而血浆黄嘌呤浓度和尿清除率不变。结论氯沙坦对尿酸盐/阴离子交换体具有高亲和力，具有一过性的促尿酸排泄作用。我们的数据表明，氯沙坦诱导次黄嘌呤的尿排泄显着减少，而黄嘌呤的变化。
Objective The acute effects of the angiotensin II receptor antagonist losartan on uric acid and oxypurine metabolism were evaluated.Methods Losartan (50 mg) was administered orally to 6 healthy males. Blood and urine samples for uric acid and oxypurine were collected before and up to 6 hours after losartan administration. The same examinations were performed later using enalapril (5 mg).Results Losartan decreased the serum uric acid concentration (from 5.9+/-0.9 to 5.2+/-1.0 mg/dl) and increased its fractional clearance, which reached a maximum after 2 hours, while enalapril did not. Losartan also induced an increase in the plasma concentration of hypoxanthine, peaking in the fourth hour, and a decrease in its urinary clearance, while the plasma xanthine concentration and its urinary clearance were unchanged. The extent of uric acid excretion was much greater than that of the oxypurines.Conclusions Losartan, which has a high affinity for the urate/anion exchanger, has a transient uricosuric effect. Our data indicate that losartan induces a significant decrease in the urinary excretion of hypoxanthine without changes in xanthine.