Recurrent Circuitry Sustains Drosophila Courtship Drive While Priming Itself for Satiety.
Recurrent Circuitry Sustains Drosophila Courtship Drive While Priming Itself for Satiety.
复制标题
循环回路维持果蝇的求偶冲动，同时为自身做好饱腹感的准备。
DOI：
10.1016/j.cub.2019.08.015
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Crickmore,MichaelA
中科院分区：
文献类型：
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作者：
Zhang,StephenX;Rogulja,Dragana;Crickmore,MichaelA
动机会在数小时或数天内增强，促进在数分钟或数小时内实现的目标，从而导致持续数小时或数天的饱腹感。在这里，我们将果蝇求爱作为一个系统来研究这些长期的动机动态。我们确定了两个参与周期性兴奋环路的神经元群，其输出会增强多巴胺信号，从而增加求爱的倾向。循环回路内的电活动随着节欲而增加，并通过活动依赖性转录因子 CREB2 驱动抑制活动的钾通道的产生。每次交配都会减少循环活动，以减少随后的求偶驱动力，并且 CREB2 在高动机期间建立的抑制循环环境会减慢几天内活动的重新积累。计算模型再现了这些行为和生理动力学，生成我们通过实验验证的预测，并说明了驱动行为的动机与目标实现后持久的饱腹感之间的因果关系。
Motivations intensify over hours or days, promoting goals that are achieved in minutes or hours, causing satiety that persists for hours or days. Here we developDrosophilacourtship as a system to study these long-timescale motivational dynamics. We identify two neuronal populations engaged in a recurrent excitation loop, the output of which elevates a dopamine signal that increases the propensity to court. Electrical activity within the recurrent loop accrues with abstinence and, through the activity-dependent transcription factor CREB2, drives the production of activity-suppressing potassium channels. Loop activity is decremented by each mating to reduce subsequent courtship drive, and the inhibitory loop environment established by CREB2 during high motivation slows the reaccumulation of activity for days. Computational modeling reproduces these behavioral and physiological dynamics, generating predictions that we validate experimentally and illustrating a causal link between the motivation that drives behavior and the satiety that endures after goal achievement.