Antigen presenting cells treated in vitro by macrophage colony-stimulating factor and autoantigen protect mice from autoimmunity
Antigen presenting cells treated in vitro by macrophage colony-stimulating factor and autoantigen protect mice from autoimmunity
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DOI：
10.1016/j.jneuroim.2007.09.021
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发表时间：
2007-12-01
影响因子：
3.3
通讯作者：
Rostami, Abdolmohamad
中科院分区：
文献类型：
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作者：
Guan, Yangtai;Yu, Shuo;Rostami, Abdolmohamad
巨噬细胞集落刺激因子（M-CSF）是单核细胞谱系发育的关键细胞因子，可能具有免疫调节特性。本研究表明，经M-CSF处理的腹膜抗原提呈细胞（APCs）产生的促炎细胞因子ifn - γ、tnf - α和IL-12水平降低。这些APCs经M-CSF+自身抗原肽处理后，在体外和体内显著抑制抗原特异性T细胞增殖，诱导调节性CD4（+）和CD8(+) T细胞，并显著抑制实验性自身免疫性脑脊髓炎（EAE）。因此，在体外用M-CSF+自身抗原治疗APCs可能是一种新的治疗自身免疫性疾病的选择。(c) 2007 Elsevier b.v.版权所有
Macrophage colony-stimulating factor (M-CSF) is a critical cytokine in the development of monocytic lineage and may have immunoregulatory properties. Here we show that peritoneal antigen presenting cells (APCs) treated with M-CSF produced decreased levels of proinflammatory cytokines IFN-gamma, TNF-alpha and IL-12. These APCs treated with M-CSF+autoantigen peptide significantly suppressed antigenspecific T cell proliferation, induced regulatory CD4(+), and CD8(+) T cells in vitro and in vivo, and significantly suppressed experimental autoimmune encephalomyelitis (EAE). Thus, in vitro treatment of APCs with M-CSF+autoantigen can be a novel therapeutic option for autoiinmune diseases. (c) 2007 Elsevier B.V All rights reserved.