PRL-3: A metastasis-associated phosphatase in search of a function
PRL-3: A metastasis-associated phosphatase in search of a function
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DOI：
10.1159/000101324
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发表时间：
2007-01-01
影响因子：
2.7
通讯作者：
Pallen, Catherine J.
中科院分区：
文献类型：
--
作者：
Bessette, Darrell C.;Wong, Patrick C. W.;Pallen, Catherine J.
尽管细胞转移是癌症死亡率的主要因素，但与肿瘤发生有关的分子和细胞事件相比，癌症进展和转移所涉及的分子和细胞事件仍然不太明确。因此，蛋白酪氨酸磷酸酶，再生肝蛋白-3（PRL-3）的表达在结肠癌转移中上调的发现提供了一个令人兴奋的迹象，即特定蛋白酪氨酸磷酸化事件和信号传导途径的调节改变可能表征这些转移细胞和/或在促进这种上皮起源的癌症以及可能其他癌症中的肿瘤向转移的转变中是关键的。然而，PRL-3的细胞底物尚未确定，并且对PRL-3介导的细胞信号传导途径知之甚少。本文综述了PRL-3在促进肿瘤转移中的意义以及确定PRL-3内源性作用的重要性。版权所有（c）2007 S. Karger AG，巴塞尔。
The molecular and cellular events involved in cancer progression and metastasis remain much less well-defined than those involved in oncogenesis, despite the fact that cell metastasis is the major factor in cancer mortality. Thus, the discovery that the expression of a protein tyrosine phosphatase, protein of regenerating liver-3 (PRL-3), is upregulated in colon cancer metastases provided an exciting indication that the altered regulation of specific protein tyrosine phosphorylation events and signaling pathways might characterize these metastatic cells and/or be key in promoting the tumor-to-metastasis transition in this, and perhaps other, cancers of epithelial origin. However, the cellular substrate (s) of PRL-3 has not been identified, and little is known of PRL-3-mediated cellular signaling pathways. This review illustrates the significance of PRL-3 in promoting metastasis and the importance of determining the endogenous role of PRL-3. Copyright (c) 2007 S. Karger AG, Basel.