CRUMBS ENCODES AN EGF-LIKE PROTEIN EXPRESSED ON APICAL MEMBRANES OF DROSOPHILA EPITHELIAL-CELLS AND REQUIRED FOR ORGANIZATION OF EPITHELIA
CRUMBS ENCODES AN EGF-LIKE PROTEIN EXPRESSED ON APICAL MEMBRANES OF DROSOPHILA EPITHELIAL-CELLS AND REQUIRED FOR ORGANIZATION OF EPITHELIA
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DOI：
10.1016/0092-8674(90)90189-l
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发表时间：
1990-06-01
期刊：
影响因子：
64.5
通讯作者：
KNUST, E
中科院分区：
文献类型：
--
作者：
TEPASS, U;THERES, C;KNUST, E
我们描述了果蝇基因碎片的分子特征，它编码一个完整的膜蛋白与30 EGF样重复的细胞外部分，并表现出惊人的表达模式。该蛋白仅定位于上皮细胞的顶膜上，并集中在细胞之间的边界处。碎屑中的突变导致外胚层来源的上皮组织的严重破坏，并且在某些情况下导致这些组织中的细胞死亡。蛋白质的结构和表达模式以及突变的表型表明在上皮细胞发育期间碎屑的功能，可能用于建立和/或维持细胞极性。
We describe the molecular characterization of the Drosophila gene crumbs, which encodes an integral membrane protein with 30 EGF-like repeats in the extracellular part and exhibits a striking expression pattern. The protein is exclusively localized on the apical membranes of epithelial cells and concentrated at the borders between cells. Mutations in crumbs lead to severe disruptions in the organization of ectodermally derived epithelia and in some cases to cell death in these tissues. The structure and the expression pattern of the protein and the phenotype of mutations indicate a function of crumbs during the development of epithelia, possibly for the establishment and/or maintenance of cell polarity.