Decreased thalamic expression of the homeobox gene DLX1 in psychosis
Decreased thalamic expression of the homeobox gene DLX1 in psychosis
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DOI：
10.1001/archpsyc.60.9.869
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发表时间：
2003-09-01
影响因子：
--
通讯作者：
Kahn, RS
中科院分区：
文献类型：
--
作者：
Kromkamp, M;Uylings, HBM;Kahn, RS
内容：精神分裂症和双相情感障碍患者的丘脑回路异常可能与共同的精神病易感性有关，并且可能是这些疾病之间的遗传联系。目的：探讨精神分裂症和双相情感障碍患者丘脑DLX 1和SHOX 2基因表达模式的差异（别名OG 12 X或SHOT）与精神病和非精神病对照受试者的比较。设计：死后切片含有丘脑背内侧核进行原位杂交与小鼠Dlx 1和人类SHOX 2 RNA探针。DLX 1和SHOX 2阳性神经元相对于Nissl染色神经元的数量在系统随机取样体积探针中估计。患者：15名精神分裂症患者，15名有或没有精神病史的双相情感障碍患者，15名重度抑郁症患者，和15名来自斯坦利基金会脑库的非精神病对照。与精神病和非精神病对照组相比，有精神病史的精神分裂症和双相情感障碍患者DLX 1和SHOX 2阳性神经元的相对数量。有精神病史的患者显示DLX 1-与无精神病史的患者和非精神病对照组相比，SHOX 2阳性神经元的相对数量无差异（P> 0.15）。结果获得盲目的诊断，症状，或），其他变量除了semi.Conclusion：丘脑表达DLX 1的精神分裂症和双相情感障碍与精神病表明共享的遗传缺陷，这种同源异型盒基因的表达。
Context: A shared vulnerability to develop psychosis can be related to abnormalities in thalamic circuits in schizophrenia and bipolar disorder and could be a genetic link between these disorders. Homeobox genes involved in development and differentiation of the brain could play an important role in these disorders.Objective: To determine whether patients with schizophrenia and bipolar disorder have different thalamic expression patterns of 2 homeobox genes, DLX1 and SHOX2 (alias OG12X or SHOT) compared with psychiatric and nonpsychiatric control subjects.Design: Postmortem sections containing the thalamic mediodorsal nucleus were subjected to in situ hybridization with mouse Dlx1 and human SHOX2 RNA probes. The number of both DLX1- and SHOX2-positive neurons relative to Nissl-stained neurons was estimated in systematic randomly sampled volume probes.Patients: Fifteen patients with schizophrenia, 15 with bipolar disorder with or without history of psychosis, 15 with major depressive disorder, and 15 nonpsychiatric controls from the Stanley Foundation Brain Bank.Main Outcome Measure: Relative numbers of DLX1-and SHOX2-positive neurons in patients with schizophrenia and bipolar disorder with history of psychosis compared with psychiatric and nonpsychiatric controls.Results: Patients with a history of psychosis showed significantly decreased relative numbers of DLX1-positive neurons compared with patients without history of psychosis and nonpsychiatric controls (P=.02), whereas no differences could be found in relative numbers of SHOX2-positive neurons (P>.15). Results were obtained blind to diagnosis, symptoms, or an), other variable except hemisphere.Conclusion: Decreased thalamic expression of DLX1 in schizophrenia and bipolar disorder with psychosis suggests shared genetic deficits in expression of this homeobox gene.