Lessons of organ-induced tolerance learned from historical clinical experience.
Lessons of organ-induced tolerance learned from historical clinical experience.
复制标题
从历史临床经验中吸取器官诱导耐受的教训。
DOI：
10.1097/01.tp.0000117780.74133.74
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发表时间：
2004
期刊：
影响因子：
6.2
通讯作者：
Fung,JohnJ
中科院分区：
文献类型：
--
作者：
Starzl,ThomasE;Murase,Noriko;Demetris,AnthonyJ;Trucco,Massimo;Abu-Elmagd,Kareem;Gray,EdwardA;Eghtesad,Bijan;Shapiro,Ron;Marcos,Amadeo;Fung,JohnJ
虽然还原论的方法已经为科学服务了400年，但如果最初的前提是不正确的，细节的积累可能会掩盖真相。一个这样的前提是，成功的器官移植和骨髓移植是根本不同的结果，涉及单独和不同的机制。一些历史性的临床观察结果几乎从一开始就指出了不同的结论，并包括如何借助免疫抑制诱导耐受的线索。
Although the reductionist approach has served science well for 400 years, the accumulation of details can obscure the truth if the original premise is incorrect. One such premise has been that successful organ transplantation and bone marrow engraftment are fundamentally different outcomes involving separate and distinct mechanisms. Some historical clinical observations pointed to a different conclusion almost from the beginning and included clues about how to induce tolerance with the aid of immunosuppression.