Dopaminergic modulation of neuronal activity in the monkey putamen through D1 and D2 receptors during a delayed Go/Nogo task
Dopaminergic modulation of neuronal activity in the monkey putamen through D1 and D2 receptors during a delayed Go/Nogo task
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DOI：
10.1007/s002210050217
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发表时间：
1997-11-01
影响因子：
2
通讯作者：
Tanji, J
中科院分区：
文献类型：
--
作者：
Inase, M;Li, BM;Tanji, J
使用多管玻璃微量移液器，我们记录了单个单位的活动在壳核，和离子电渗应用D1和D2多巴胺受体激动剂（SKF 38393，quinpirole）和拮抗剂（SCH 23390，舒必利），而两只猴子正在执行延迟去/Nogo任务。在Go和Nogo试验中，壳核神经元在各个任务期（保持期、提示期、延迟期、反应期和奖励期）都表现出活动变化。在296个任务相关的壳核神经元中，87个仅在Go试验中显示活动变化（Go型），74个仅在Nogo试验中显示活动变化（Nogo型），99个在两个试验中在相同的任务期间显示活动变化（两种类型），36个在两个试验中但在不同的任务期间显示活动变化（不同类型）。这296个神经元进行了检查D1和D2激动剂和/或拮抗剂的影响，和234个神经元响应D1或D2相关物质或两者。其中41%的神经元只对D1物质有反应（D1组），36%的神经元只对D2物质有反应（D2组），23%的神经元对D1和D2物质都有反应（D1 D2组）。在D1和D2物质的离子电渗应用过程中，大多数响应神经元改变了它们的任务相关活动，但没有改变它们的基线放电率。DI激动剂在19个神经元中增加活性，在105个神经元中降低活性。另一方面，D2激动剂在54个神经元中增加活性，在50个神经元中降低活性。D1和D2物质在Go和Nogo试验中调节活性。三个D1/D2组（D1、D2和D1 D2组）中的每一个都包含所有四种Go/Nogo类型（Go、Nogo、两者和不同类型）的神经元。各Go/Nogo型神经元的体积在三个D1/D2组之间是相当的。D1和D2物质调节与不同任务时期相关的活动。三个D1/D2组中的每一个都包括在Go和Nogo试验中的提示，延迟，反应或奖励期间激活的神经元。D1/D2组与各任务期相关的神经元分布相似。这些结果表明，多巴胺可以通过D1和D2受体调节单个壳核神经元的活性，并且通过壳核中的两种受体的多巴胺能调节影响行为控制中的类似类型的信号。
Using multibarreled glass micropipettes, we recorded single-unit activity in the putamen, and iontophoretically applied D1 and D2 dopamine receptor agonists (SKF38393, quinpirole) and antagonists (SCH23390, sulpiride) while two monkeys were performing a delayed Go/Nogo task. The putaminal neurons exhibited changes in activity during various task periods (hold, cue, delay, response, and reward periods) in both Go and Nogo trials. Of 296 task-related putaminal neurons, 87 showed activity changes in Go trials only (Go type), 74 in Nogo trials only (Nogo type), 99 in both trials during the same task periods (Both type), and 36 in both trials but during different task periods (Different type). These 296 neurons were examined as regards the effects of both D1 and D2 agonists and/or antagonists, and 234 neurons responded to either D1- or D2-related substances or both. Among them 41% of neurons responded to the D1 substances only (D1 group), 36% responded to the D2 substances only (D2 group), and 23% responded to both D1 and D2 substances (D1D2 group). During the iontophoretic application of the D1 and D2 substances, most of the responding neurons changed their task-related activity but not their baseline firing rates. The DI agonist increased the activity in 19 neurons and decreased it in 105 neurons. On the other hand, the D2 agonist increased the activity in 54 neurons and decreased it in 50 neurons. The D1 and D2 substances modulated the activity in both Go and Nogo trials. Each of the three D1/D2 groups (D1, D2, and D1D2 groups) contained all four Go/Nogo types (Go, Nogo, Both, and Different types) of neurons. Percentages of each Go/Nogo type of neuron were comparable among the three D1/D2 groups. The D1 and D2 substances modulated the activity related to various task periods. Each of the three D1/D2 groups included neurons activated during the cue, delay, response, or reward period in Go and Nogo trials. Distributions of the neurons related to each task period were similar among the D1/D2 groups. These results suggest that dopamine can modulate the activity of single putaminal neurons through both D1 and D2 receptors and that the dopaminergic modulation through the two receptors in the putamen affects similar types of signals in behavioral control.