The "inhibitory" effect of high-frequency stimulation and the excitation state of nerve.
The "inhibitory" effect of high-frequency stimulation and the excitation state of nerve.
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DOI：
10.1113/jphysiol.1935.sp003238
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发表时间：
1935-03-01
影响因子：
5.5
通讯作者：
Gerard, RW
中科院分区：
文献类型：
--
作者：
Cattell, M;Gerard, RW
在大多数情况下，低频刺激（约每秒500次）。施加到神经干上方、下方或施加高频刺激（每秒2000次）的区域。具有相同特征的神经元能够使总动作电位达到最大，即使单独对高频的反应大大降低。在这些条件下，高频在很大程度上无法激发。最大每秒600次的刺激。在每秒1700次的速度下只能产生最大响应的3%。在其他条件下，特别是在持续时间更长的高频冲击或更频繁的低频冲击下，高频能够阻止低频脉冲通过高频区。然后，高频放电作用于神经，很像电紧张电流，在极端情况下抑制或阻断。通常情况下，高频刺激，虽然在很大程度上无法激发自己，但不会阻止低频刺激或脉冲叠加时的完全反应。
In most cases low-frequency stimuli (about 500 per sec.) applied to the nerve trunk above, below, or at the region of application of high-frequency stimuli (2000 per sec.) of identical character are able to bring the total action potential to maximal, even though the response to high frequency alone is greatly reduced. Under these conditions the high frequency is largely failing to excite. Stimuli which are maximal at 600 per sec. may give only 3% of the maximal response at 1700 per sec. Under other conditions, especially with high-frequency shocks of greater duration or with more frequent low-frequency shocks, the high frequency is able to block low-frequency impulses passing through the high region. The high-frequency discharges act upon the nerve then, much like electrotonic currents, to depress or block in extreme cases. Ordinarily, the high-frequency stimuli, while largely failing to excite themselves, do not prevent the full response when low-frequency stimuli or impulses are superimposed.