Association of soluble interleukin-2 receptor α and tumour necrosis factor receptor 1 with heart failure: The Multi-Ethnic Study of Atherosclerosis
Association of soluble interleukin-2 receptor α and tumour necrosis factor receptor 1 with heart failure: The Multi-Ethnic Study of Atherosclerosis
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DOI：
10.1002/ehf2.12623
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发表时间：
2020-04-01
影响因子：
3.8
通讯作者：
Lima, Joao A. C.
中科院分区：
文献类型：
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作者：
Bakhshi, Hooman;Varadarajan, Vinithra;Lima, Joao A. C.
目的可溶性肿瘤坏死因子- α受体1 （stnf - α R1）和白细胞介素-2受体α (sIL-2R α)预测老年人心力衰竭（HF）的发生。然而，在多民族无症状人群中，这些生物标志物与HF的关系尚不清楚。我们的目的是调查多民族中老年人群中stnf - α R1和sIL-2R α与HF事件的关系。方法和结果：动脉粥样硬化的多民族研究是一项基于人群的前瞻性研究，6814名年龄45-84岁的参与者入组时无临床心血管疾病。我们在2000-2002年的动脉粥样硬化多种族基线研究中纳入了2869名具有可用stnf - α R1或sIL-2R α水平测量的参与者。在校正了传统心血管危险因素和心脏计算机断层扫描测量的冠状动脉钙评分后，我们使用Cox比例风险模型来研究stnf - α R1和sIL-2R α与HF事件之间的关系。在纳入的参与者中，平均（标准差）年龄为61.6（10.2）岁，46.7%为男性。stnf - α R1和sIL-2R α的中位数（四分位数范围）分别为1293（1107-1547）和901 (727-1154)pg/mL。在14.2年（四分位数间距11.7-14.8年）的中位随访期间，130名参与者发生心衰。在多变量分析中，对数变换sTNF-alpha R1和sIL-2R alpha的每一个标准差增量的事件HF的风险比（95%置信区间，P值）为1.43 （1.21-1.7，P值）
Aims Soluble tumour necrosis factor-alpha receptor 1 (sTNF-alpha R1) and interleukin-2 receptor alpha (sIL-2R alpha) predict incident heart failure (HF) in the elderly population. However, the association of these biomarkers with HF in a multi-ethnic asymptomatic population is unclear. We aimed to investigate the association of sTNF-alpha R1 and sIL-2R alpha with incident HF in a multi-ethnic population of middle age and older participants.Methods and results The multi-ethnic study of atherosclerosis is a prospective population-based study of 6814 participants aged 45-84 years who were free of clinical cardiovascular disease at enrolment. We included 2869 participants with available sTNF-alpha R1 or sIL-2R alpha level measurement at baseline multi-ethnic study of atherosclerosis exam (2000-2002). We used Cox proportional-hazards model to investigate the association between sTNF-alpha R1 and sIL-2R alpha with incident HF after adjusting for traditional cardiovascular risk factors and coronary artery calcium score measured by cardiac computed tomography. Among the included participants, the mean (standard deviation) age was 61.6 (10.2) years and 46.7% were men. The median (interquartile range) sTNF-alpha R1 and sIL-2R alpha were 1293 (1107-1547) and 901 (727-1154) pg/mL. During a median follow-up of 14.2 (interquartile range: 11.7-14.8) years, 130 participants developed HF. In multivariable analysis, the hazard ratio (95% confidence interval, P value) of incident HF for each standard deviation increment of log-transformed sTNF-alpha R1 and sIL-2R alpha was 1.43 (1.21-1.7, P