A new cytotoxic cardenolide from the latex of Antiaris toxicaria
A new cytotoxic cardenolide from the latex of Antiaris toxicaria
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DOI：
10.1016/j.cclet.2008.12.043
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发表时间：
2009-04-01
影响因子：
9.1
通讯作者：
Dai, Hao Fu
中科院分区：
文献类型：
--
作者：
Gan, Yu Juan;Mei, Wen Li;Dai, Hao Fu
从见血封喉（Antiaris toxicaria (Pers.) Lesch，桑科）的乳汁中分离得到一种新的强心苷——毒见血封喉苷E（1）。其结构通过光谱数据和化学证据得以阐明。化合物1通过MTT法在体外对K562和SGC - 7901细胞系显示出显著的细胞毒性，其半数抑制浓度（IC50）值分别为0.026和0.027μg/mL。（C）2008郝富戴。由爱思唯尔出版集团代表中国化学会出版。版权所有。
A new cardenolide, toxicarioside E (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceac). Its structure was elucidated on the basis of spectral data and chemical evidence. Compound 1 showed significant cytotoxicity against K562 and SGC-7901 cell lines in vitro by MTT method with the IC50 value of 0.026 and 0.027 mu g/mL, respectively. (C) 2008 Hao Fu Dai. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.