Evaluation of hormone receptor expression for use in predicting survival of female dogs with malignant mammary gland tumors
Evaluation of hormone receptor expression for use in predicting survival of female dogs with malignant mammary gland tumors
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DOI：
10.2460/javma.235.4.391
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发表时间：
2009-08-15
影响因子：
1.9
通讯作者：
Chang, Shih-Chieh
中科院分区：
文献类型：
--
作者：
Chang, Chao-Chin;Tsai, Min-Hsuan;Chang, Shih-Chieh
评价犬恶性乳腺肿瘤中激素受体表达的预后潜力。设计-队列研究。动物-89只患有恶性乳腺肿瘤的雌性犬和24只患有良性乳腺肿瘤的雌性犬。程序-患有恶性乳腺肿瘤的雌性犬对89例犬乳腺肿瘤和24例良性乳腺肿瘤雌激素受体（ER）表达的预后价值进行了评价结果在本研究中，68（60.2%）和88（779%）的113只狗乳腺肿瘤表达ER α和PR，分别。良性肿瘤中ER α和PR的表达频率（分别为23/24（95.8%）和24/24 [100%]）比恶性肿瘤（45/89 [50.6%]和64/89 [71.9%]）更高。ER α和PB阳性结果的肿瘤百分比在直径<5cm的肿瘤中显著更高;临床分期为I、II或III;并且没有转移到淋巴结或远处转移。然而，只有肿瘤细胞中的PR表达与手术切除肿瘤后的1年生存率显著相关。此外，狗的恶性肿瘤表达ER α和PR有一个显着更高的生存率，与狗的恶性肿瘤表达ER α，但没有PR的比率。结论和临床相关性，这些研究结果强烈表明，PR的表达可以作为一个预后因素的生存，特别是在雌犬恶性乳腺肿瘤与ER α表达。（美国兽医医学杂志2009;235：391-396）
Objective-To evaluate the prognostic potential of expression of hormone receptors in malignant mammary gland tumors of dogs.Design-Cohort study.Animals-89 female dogs with malignant mammary gland tumors and 24 female dogs with benign mammary gland tumors.Procedures-Female dogs with malignant (n = 89 dogs) and benign (24) mammary gland tumors were evaluated to determine the prognostic value of the expression of estrogen receptor (ER)alpha or the progesterone receptor (PR), as determined by use of immunohistochemical methods.Results-In this study, 68 (60.2%) and 88 (779%) of the 113 dogs with mammary gland tumors had expression of ER alpha and PR, respectively. Expression of ER alpha and PR was detected proportionately more frequently in benign tumors (23/24 (95.8%] and 24/24 [100%], respectively) than in malignant tumors (45/89 [50.6%] and 64/89 [71.9%]). Percentage of tumors with positive results for ER alpha and PB was significantly higher in tumors < 5 cm in diameter; as clinical stage I, II or III; and without metastasis to lymph nodes or distant metastasis. However, only PR expression in tumor cells was significantly associated with 1-year survival after surgical removal of the tumor. Moreover, dogs with malignant tumors expressing ER alpha and PR had a significantly higher survival rate, compared with the rate for dogs with malignant tumors expressing ER alpha but not PR.Conclusions and Clinical Relevance-These findings strongly suggested that expression of PR could be used as a prognostic factor for survival, especially in female dogs with malignant mammary gland tumors with ERa expression. (J Am Vet Med Assoc 2009;235:391-396)