Effect of spinal cord injury and its lesion level on stretch reflex modulation by cold stimulation in humans
Effect of spinal cord injury and its lesion level on stretch reflex modulation by cold stimulation in humans
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DOI：
10.1016/j.clinph.2010.05.028
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发表时间：
2011-01-01
影响因子：
4.7
通讯作者：
Nakazawa, K.
中科院分区：
文献类型：
--
作者：
Ogata, H.;Sayenko, D. G.;Nakazawa, K.
目的：为了确定如何在比目鱼肌短潜伏期牵拉反射幅度调制冷刺激在健全的个人和个人与完全spinal cord injury.Methods：一个初始的100秒的基线期，其次是50秒的冷刺激期。右比目鱼肌牵张反射每隔10 s激发一次，而冷刺激施加于左大腿。结果：在冷刺激过程中，牵张反射的峰-峰幅度显著增加，健全组达到基线的127 ± 21%（n = 9，P < 0.01）。类似地，在损伤水平在胸10或以下的组（n = 4）中，牵张反射增加高达125 +/- 11%，尽管这种增加不显著。另一方面，在胸6或以上损伤水平组中，牵张反射显著下降至78 ± 20结论：冷刺激引起的传入神经对牵张反射调制的影响因中枢神经系统参与调制的程度不同而不同。我们的研究结果提供了一个更好的理解传入传出脊髓反射通路的一些基本变化，可能不是单突触的性质。(C)2010年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To determine how short-latency stretch reflex amplitude in the soleus muscle is modulated by cold stimulation in able-bodied individuals and individuals with complete spinal cord injury.Methods: An initial 100-s baseline period was followed by 50-s cold stimulation periods. Stretch reflex of the right soleus muscle was elicited for 10-s intervals, while cold stimulation was applied to the left thigh.Results: Peak-to-peak amplitude of the stretch reflex increased significantly during cold stimulation up to 127 +/- 21% of the baseline in the able-bodied group (n = 9, P < 0.01). Similarly, stretch reflex increased up to 125 +/- 11% in a group with injury level at or below thoracic 10 (n = 4), although this increase was not significant. On the other hand, stretch reflex decreased significantly down to 78 +/- 20% in a group with injury level at or above thoracic 6 (n = 8, P < 0.05).Conclusions: Effect of afferent inputs induced by cold stimulation on stretch reflex modulation is different depending on the extent of central nervous systems participating in the modulation.Significance: Our findings provide a better understanding of some basic changes in afferent-efferent spinal reflex pathways which are probably not monosynaptic in nature. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.