Human Emerging and Re-emerging Infections - Viral and Parasitic Infections
Human Emerging and Re-emerging Infections - Viral and Parasitic Infections
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人类新发和再发感染 - 病毒和寄生虫感染
DOI：
10.1002/9781118644843.ch44
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Benbow M
中科院分区：
文献类型：
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作者：
Benbow M
布鲁里溃疡是继结核病和麻风病之后第三大常见的分枝杆菌病。虽然布鲁里溃疡被认为与人类经常光顾的景观和水体的大规模和小规模干扰有关，但布鲁里溃疡的一级预防是困难的，因为传播方式尚不清楚。本章回顾了布鲁里溃疡最常见的环境风险因素和最近的研究了解其传输。据预测，受真菌内酯影响的蛋白质可能具有共同的潜在生产机制，可以解释它们的协同调节。关于Mycolac-tone抑制机制的早期工作是使用ASL在Jurkat T细胞中进行的，重点是抑制IL-2的产生。多学科的治疗和患者护理方法对于优化治疗结果至关重要。物理治疗是最重要的减少和/或预防残疾。
Buruli Ulcer (BU) is the third most commonmycobacteriumdisease following only tuberculosis and leprosy. Though BU is thought to be associated with large‐and small‐scale disturbances to the landscape and bodies of water frequented by human populations, primary prevention of BU is difficult because the mode of transmission is not known. This chapter reviews the most common environmental risk factors for BU and recent research into understanding its transmission. It is predicted that the proteins affected by mycolactone may share an underlying mechanism of production that could explain their co‐regulation. Early work on the mechanism of suppression by mycolac‐tone was carried out in Jurkat T cells using ASLs and focused on the suppression of IL‐2 production. A multidisciplinary approach to treatment and patient care is essential for optimizing treatment outcomes. Physiotherapy is paramount minimizing and/or preventing disabilities.