Repetitive, negligible force reaching in rats induces pathological overloading of upper extremity bones
Repetitive, negligible force reaching in rats induces pathological overloading of upper extremity bones
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DOI：
10.1359/jbmr.2003.18.11.2023
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发表时间：
2003-11-01
影响因子：
6.2
通讯作者：
Barbe, MF
中科院分区：
文献类型：
--
作者：
Barr, AE;Safadi, FF;Barbe, MF
与工作相关的重复性运动障碍是昂贵的。本文观察了17只大鼠反复伸手抓握后骨骼的免疫组织化学变化。3-6周后，伸侧和非伸侧前肢肌肉、骨间膜附着处骨膜表面和干骺端ED 1（+）巨噬细胞和破骨细胞数量增加。这些发现表明病理性超负荷导致炎症和随后的骨吸收。
Work-related repetitive motion disorders are costly. Immunohistochemical changes in bones resulting from repetitive reaching and grasping in 17 rats were examined. After 3-6 weeks, numbers of ED1(+) macrophages and osteoclasts increased at periosteal surfaces of sites of muscle and interosseous membrane attachment and metaphyses of reach and nonreach forelimbs. These findings indicate pathological overloading leading to inflammation and subsequent bone resorption.