Hypothalamic-Pituitary-Testicular Axis Function in Endurance-Trained Males
Hypothalamic-Pituitary-Testicular Axis Function in Endurance-Trained Males
复制标题
耐力训练男性的下丘脑-垂体-睾丸轴功能
DOI：
10.1055/s-2007-1024811
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发表时间：
1990
影响因子：
2.5
通讯作者：
Ph. D A. C. Hackney
中科院分区：
文献类型：
--
作者：
A. Hackney;andB. C W. E. Sinning';Bruot2;Ph. D A. C. Hackney
在经过耐力训练（TRG）和未经训练（UNT）的男性组中评估下丘脑-垂体-睾丸（H-P-T）轴。每组均接受：1) 4 小时静息激素分析 [睾酮 (T)、游离睾酮 (FT)、雌二醇 (E2)、黄体生成素 (LH)、催乳素 (PRL) 和皮质醇 (C)]，2) 对垂体睾丸进行多巴胺拮抗剂（DA；10 微克.kg-1 体重）攻击，3)促性腺激素释放激素（GnRH；120 微克.kg-1 体重）对垂体睾丸的攻击。与 UNT 相比，TRG 静息 T（4.8 +/- 0.7 对比 7.1 +/- 1.2 ng.ml-1，p = 0.05）和 PRL（3.3 +/- 1.4 对比 7.0 +/- 2.3 ng.ml-1，p = 0.09）较低，而 LH 升高（15.0 +/- 1.8 对比 11.8 +/- 1.5） mIU.ml-1，p = 0.06）。 DA 挑战在 TRG 中产生的综合 PRL 反应（2962.7 +/- 265.1 ng +/- ml-1.min）比在 UNT 中（1735.3 +/- 282.0 ng.ml-1.min；p = 0.01）更高。 DA 诱导的 PRL 升高后，未观察到 T 发生显着变化。与 UNT 相比，注射 GnRH 后 TRG 的 LH 反应减弱（817.2 +/- 111.6 mIU.ml-1.min）（1493.7 +/- 213.4 mIU.ml-1.min；P 小于 0.02）。 GnRH 激发后 LH 升高，两组 T 水平均显着升高（p 小于 0.03）（分别为 TRG = 9.9 +/- 5.0%；UNT = 8.6 +/- 9.9%），但未观察到组间显着差异。结果表明，耐力训练可增强 PRL 并减弱垂体释放的 LH。（摘要截断为 250 字）
The hypothalamic-pituitary-testicular (H-P-T) axis was evaluated in groups of endurance-trained (TRG) and untrained (UNT) males. Each group was subjected to: 1) a 4-h resting hormonal profile [testosterone (T), free-testosterone (FT), estradiol (E2), luteinizing hormone (LH), prolactin (PRL), and cortisol (C)], 2) a dopamine antagonist (DA; 10 micrograms.kg-1 body weight) challenge to the pituitary-testes, and 3) a gonadotropin-releasing hormone (GnRH; 120 micrograms.kg-1 body weight) challenge to the pituitary-testes. Compared to UNT, the TRG resting T (4.8 +/- 0.7 vs 7.1 +/- 1.2 ng.ml-1, p = 0.05) and PRL (3.3 +/- 1.4 vs 7.0 +/- 2.3 ng.ml-1, p = 0.09) were lower while LH was elevated (15.0 +/- 1.8 vs 11.8 +/- 1.5 mIU.ml-1, p = 0.06). The DA challenge produced a greater integrated PRL response in the TRG (2962.7 +/- 265.1 ng +/- ml-1.min) than in the UNT (1735.3 +/- 282.0 ng.ml-1.min; p = 0.01). No significant changes were observed in T following the DA-induced PRL rise. The TRG had a blunted LH response (817.2 +/- 111.6 mIU.ml-1.min) following the GnRH injection as compared to the UNT (1493.7 +/- 213.4 mIU.ml-1.min; P less than 0.02). T levels were significantly (p less than 0.03) increased in both groups by the LH rise after the GnRH challenge (TRG = 9.9 +/- 5.0%; UNT = 8.6 +/- 9.9%, respectively), but no significant between group differences were observed. Results suggest endurance training produces an enhanced PRL and attenuated LH release by the pituitary.(ABSTRACT TRUNCATED AT 250 WORDS)