Effect of dietary fiber on colonic cell proliferation and its relationship to colon carcinogenesis.
Effect of dietary fiber on colonic cell proliferation and its relationship to colon carcinogenesis.
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膳食纤维对结肠细胞增殖的影响及其与结肠癌发生的关系。
DOI：
10.1016/0091-7435(87)90073-9
复制
发表时间：
1987
影响因子：
5.1
通讯作者：
Jacobs,LR
中科院分区：
文献类型：
--
作者：
Jacobs,LR
在实验室啮齿动物中，向半纯化饮食中添加特定纤维补充剂已被证明可刺激大肠细胞增殖。相对不溶性的纤维，如发酵较差的纤维素，更易溶解的燕麦麸皮和惰性填充剂，如高岭土，对细胞生长几乎没有影响。另一方面，麦麸、果胶、瓜尔胶和降解的角叉菜胶都刺激大肠细胞增殖，最大的生长反应往往发生在盲肠或近端结肠。近端大肠也是膳食纤维和任何其他未吸收碳水化合物的肠道发酵的主要场所。结肠微生物对纤维的发酵导致短链脂肪酸的产生和大肠内容物的较低pH值，已知代谢事件与上皮细胞生长增加相关。一般来说，刺激细胞生长的因素也会促进肿瘤的发展，这一概念在结肠中也适用，即使是果胶和瓜尔胶等膳食纤维。麦麸也可以刺激结肠癌发生时，只在致癌物暴露喂养。燕麦麸皮和玉米麸皮可能通过增加粪便胆汁酸排泄（许多可溶性纤维的一个特征）刺激结肠癌发生，而大肠内容物的酸化与化学诱导的结肠癌频率增加有关。需要对结肠代谢和细胞生理学有更深入的了解，以充分确定膳食纤维改变结肠癌发展的机制。
The addition of specific fiber supplements to semipurified diets has been shown to stimulate large bowel cell proliferation in laboratory rodents. Relatively insoluble fibers such as cellulose, which is poorly fermented, the more-soluble oat bran, and inert bulking agents such as kaolin produce little or no effect on cell growth. On the other hand, wheat bran, pectin, guar gum, and degraded carageenan all stimulate large bowel cell proliferation, the greatest growth response tending to occur in the cecum or proximal colon. The proximal large bowel is also the major site for the intestinal fermentation of dietary fiber and any other nonabsorbed carbohydrates. The fermentation of fiber by colonic microorganisms results in the production of short-chain fatty acids and a lower pH of large bowel contents, metabolic events known to be associated with increased epithelial cell growth. In general, factors that stimulate cell growth also enhance tumor development, a concept that holds true in the colon even for dietary fibers such as pectin and guar gum. Wheat bran can also stimulate colon carcinogenesis when fed only during carcinogen exposure. Oat bran and corn bran may stimulate colon carcinogenesis by increasing fecal bile acid excretion, a feature of many soluble fibers, while the acidification of large bowel contents is associated with an increased frequency of chemically induced colonic cancers. A greater understanding of colonic metabolism and cell physiology is needed to define fully the mechanisms by which dietary fibers modify colon cancer development.
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膳食纤维水平对兔子体重增加、盲肠体积和挥发性脂肪酸产生的影响。
DOI：
10.1093/jn/102.3.375
发表时间：
1972
期刊：
The Journal of nutrition
影响因子：
--
作者：
W. Hoover;R. Heitmann
通讯作者：
R. Heitmann
DOI：
10.1093/jn/100.5.545
发表时间：
1970
期刊：
The Journal of nutrition
影响因子：
--
作者：
M. Yang;K. Manoharan;O. Mickelsen
通讯作者：
O. Mickelsen
DOI：
--
发表时间：
1965
期刊：
影响因子：
--
作者：
P. Ms;Palmer Va
通讯作者：
Palmer Va
影响因子：
3.2
作者：
FATH, RB;DESCHNER, EE;DWORKIN, BM
通讯作者：
DWORKIN, BM
杂食性非反刍动物后肠对碳水化合物和含氮物质的消化和吸收。
影响因子：
3.3
作者：
A. Rérat
通讯作者：
A. Rérat