The relationship between dietary fat intake and risk of colorectal cancer: Evidence from the combined analysis of 13 case-control studies
The relationship between dietary fat intake and risk of colorectal cancer: Evidence from the combined analysis of 13 case-control studies
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DOI：
10.1023/a:1018476414781
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发表时间：
1997-03-01
影响因子：
2.3
通讯作者：
Shu, Z
中科院分区：
文献类型：
--
作者：
Howe, GR;Aronson, KJ;Shu, Z
本研究的目的是研究膳食脂肪摄入量对结直肠癌风险的影响，并对先前在不同结直肠癌发病率和饮食习惯的人群中进行的13项病例对照研究的数据进行综合分析。将5，287例结直肠癌和10，470例对照的原始数据记录合并。Logistic回归分析用于估计总能量、总脂肪及其组分和胆固醇摄入量的比值比（OR）。13项研究中有11项与能量摄入呈正相关。然而，几乎没有证据表明总脂肪的任何能量独立效应，总脂肪摄入量残差的五分位数OR分别为1.00、0.95、1.01、1.02和0.92（P趋势= 0.67）或饱和脂肪，OR为1.00、1.08、1.06、1.21和1.06（P趋势= 0.39）。分析表明，在这些病例对照研究中，膳食脂肪摄入量与结直肠癌风险之间没有能量独立相关性。它还表明，用其他卡路里来源简单地替代脂肪不太可能有意义地降低结直肠癌的风险。
The objective of this study was to examine the effects of the intake of dietary fat upon colorectal cancer risk in a combined analysis of data from 13 case-control studies previously conducted in populations with differing colorectal cancer rates and dietary practices. Original data records for 5,287 cases of colorectal cancer and 10,470 controls were combined. Logistic regression analysis was used to estimate odds ratios (OR) for intakes of total energy, total fat and its components, and cholesterol. Positive associations with energy intake were observed for 11 of the 13 studies. However, there was little, if any, evidence of any energy-independent effect of either total fat with ORs of 1.00, 0.95, 1.01, 1.02, and 0.92 for quintiles of residuals of total fat intake (P trend = 0.67) or for saturated fat with ORs of 1.00, 1.08, 1.06, 1.21, and 1.06 (P trend = 0.39). The analysis suggests that, among these case-control studies, there is no energy-independent association between dietary fat intake and risk of colorectal cancer. It also suggests that simple substitution of fat by other sources of calories is unlikely to reduce meaningfully the risk of colorectal cancer.