Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses.
Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses.
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DOI：
10.1016/s0021-9258(18)41621-3
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发表时间：
1992-11
期刊：
影响因子：
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通讯作者：
R. Morimoto;K. Sarge;Klara Abravaya
中科院分区：
文献类型：
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作者：
R. Morimoto;K. Sarge;Klara Abravaya
热休克反应提供了一个理想的范例来理解细胞如何识别和响应环境和生理应激的急性和慢性暴露。在众多可诱导的基因组反应中，热休克反应为适应的分子和细胞机制提供了有趣的见解，从热休克基因表达的调节到应激蛋白的功能。最近在高等真核生物中克隆了多个热休克转录因子(HSF)基因，并对HSF的生化和细胞特性进行了研究，揭示了转录反应的一些新特征。
The heat shock response offers an ideal paradigm to understand how the cell recognizes and responds to acute and chronic exposures to environmental and physiological stress. Of the numerous inducible genomic responses, the heat shock response has contributed fascinating insights into the molecular and cellular mechanisms of adaptation, ranging from the regulation of heat shock gene expression to the function of stress proteins. The recent cloning of multiple heat shock transcription factor (HSF) genes in higher eukaryotes and studies on the biochemical and cellular properties of HSFs have revealed several novel features of the transcriptional response.