Enhanced pancreatic and skin tumorigenesis in cabbage-fed hamsters and mice.
Enhanced pancreatic and skin tumorigenesis in cabbage-fed hamsters and mice.
复制标题
增强卷心菜喂养的仓鼠和小鼠的胰腺和皮肤肿瘤发生。
DOI：
10.1093/carcin/8.7.913
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发表时间：
1987
期刊：
影响因子：
4.7
通讯作者：
Bresnick,E
中科院分区：
文献类型：
--
作者：
Birt,DF;Pelling,JC;Pour,PM;Tibbels,MG;Schweickert,L;Bresnick,E
本研究旨在评价日粮中添加干卷心菜对仓鼠胰腺癌和小鼠皮肤肿瘤的抑制作用。用40 mg/kg体重的亚硝酸双氧丙胺(BOP)诱发胰腺癌。在低脂饲料中饲喂致癌物处理前的甘蓝，并在BOP处理后1周开始，分别饲喂低脂和高脂饲料，并与各自不含甘蓝的饲料进行比较。干卷心菜分别以9%和11%的水平添加到低脂肪和高脂肪饲料中。与低脂饲料喂养的金黄地鼠或高脂饲料不含甘蓝饲料的金黄地鼠相比，高脂饲料喂养的卷心菜可提高BOP诱发的小鼠胰腺导管癌的产量(1.6个/只动物)(P<0.0 5)，而不喂饲高脂饲料的金黄地鼠则为0.6~0.8个/只动物(P≤0.0 5)。此外，无论饮食脂肪摄入量如何，喂食卷心菜的仓鼠都会增加BOP诱发的胆囊腺激素的发生率。描述了膳食脂肪和卷心菜对食物摄入量、体重以及血清T3和T4值的影响。用10-N-甲基-7，12-二甲基苯并[a]蒽(DMBA)诱发Sencar小鼠皮肤肿瘤形成，1周后开始用2μg 12-O-十四酰-13-佛波醇醋酸酯(TPA)每周两次，促进皮肤肿瘤的形成。在DMBA处理前和整个TPA处理过程中，将干甘蓝添加到AIN半纯饲料中。在DMBA引发的TPA促进的小鼠中，喂食含有10%卷心菜的食物的小鼠皮肤乳头状瘤产量增加。经过22周的推广，喂食卷心菜的小鼠平均每只小鼠患上8.45个乳头状瘤，而对照组小鼠每只患上7.25个乳头状瘤(P<；0.001)。甘蓝饲喂对小鼠的存活、摄食量和体重没有影响。这些结果表明，有必要对卷心菜作为化学预防措施进行进一步研究。
Studies were conduded to evaluate the ability of dietary dried cabbage supplements to inhibit pancreatic carcinogenesis in hamsters and skin tumorigenesis in mice. Pancreatic cancer was induced by treatment with 40 mg/kg body wtN-nitrosobis-(2oxopropyl)amine (BOP). Cabbage was fed from before carcinogen treatment in low fat diet and, beginning 1 week after BOP treatment, cabbage was given in low fat and high fat diets in comparison with the respective non-cabbage containing diets. Dried cabbage was incorporated at 9 and 11% levels into the low and high fat diets. Feeding cabbage in the high fat diet elevated the yield of BOP-induced pancreatic ductular cardnoma (1.6 carcinomas/effedive animal) in comparison with that observed in hamsters fed cabbage in a low fat diet or in those given a high fat diet without cab bage, 0.6–0.8 carcinomaa/effedive animal (P ≤ 0.05). Furthermore, the incidence of BOP-induced gall bladder adenocadnomm was elevated in cabbage-fed hamsters irrespedve of dietary fat intake. Effets of dietary fat and cabbage on food consumption, body weight, and serum T3and T4values are described. Skin tumorigenesis was induced in SENCAR mice by 10 nmd 7,12 dlmethylbenz[a]anthracene (DMBA) and promoted beginning 1 week later with twice weekly applications of 2 μg 12-O-tetradecanoyl-13-phorbol acetate (TPA). Dried cabbage was incorporated into AIN semi-purified diets from before DMBA treatment and throughout TPA treatment. Skin papilloma yield was elevated in DMBA-initiated TPA-promoted mice that were fed diets containing 10% cabbage. Mice fed cabbage developed an average of 8.45 papillomas per mouse following 22 weeks of promotion while mice given control diet developed 7.25 papillomas per mouse (P < 0.001). Cabbage feeding did not influence survival, food consumption or body weight of the mice. These results suggest the need for further research on the use of cabbage as a chemopreventive measure.