Neuropathology in patients with congenital heart disease and Down syndrome.
Neuropathology in patients with congenital heart disease and Down syndrome.
复制标题
先天性心脏病和唐氏综合症患者的神经病理学。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
L. Becker
中科院分区：
文献类型：
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作者：
T. Mito;P. Pereyra;L. Becker
本文分析了唐氏综合征（45例）、孤立性冠心病（296例）和冠心病合并多发性异常（92例）三组患者的神经病理学表现与先天性心脏病（CHD）的关系。唐氏综合症患者的脑重量增加在1岁之前与对照标准相似，之后则低于正常水平。三组间青紫型冠心病发生率、手术史、肉眼及显微镜下脑畸形均有差异。唐氏综合症患者大脑钙化的发生率增加。整个队列中有9名儿童有脑血管异常。虽然冠心病在唐氏综合征中很常见，但脑血管系统却幸免；仅检出少见的Willis环轻微异常。
This report examines the relationship between congenital heart disease (CHD) and neuropathological findings in three groups of patients: Down syndrome (45 cases), isolated CHD (296 cases), and CHD with multiple anomalies (92 cases). The increase in brain weight in Down syndrome was similar to control standards up to 1 year of age, after which it was less than normal. Among the three groups, there were differences in frequency in cyanotic CHD, history of operation, and macroscopic and microscopic brain malformations. The incidence of calcification in the brain was increased in Down syndrome. Nine children out of the total cohort had cerebrovascular abnormalities. Although CHD is frequent in Down syndrome, the cerebrovasculature is spared; only infrequent minor abnormalities of the circle of Willis were detected.