An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019
An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019
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DOI：
10.1093/cid/ciaa577
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发表时间：
2020-10-15
影响因子：
11.8
通讯作者：
Agrati, Chiara
中科院分区：
文献类型：
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作者：
Bordoni, Veronica;Sacchi, Alessandra;Agrati, Chiara
2019年冠状病毒病患者炎性细胞因子和髓系来源的抑制细胞产生增加。这些与表达穿孔素的自然杀伤细胞(NK)和CD3(+)T细胞呈负相关。我们观察到重症监护病房(ICU)患者与非ICU患者相比，表达穿孔素的NK细胞数量较少，这表明免疫细胞毒臂的损伤是一种致病机制。
Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3(+) T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.