Neural responses to acute cocaine administration in the human brain detected by fMRI
Neural responses to acute cocaine administration in the human brain detected by fMRI
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DOI：
10.1016/j.neuroimage.2005.06.039
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发表时间：
2005-12-01
期刊：
影响因子：
5.7
通讯作者：
Li, SJ
中科院分区：
文献类型：
--
作者：
Kufahl, PR;Li, Z;Li, SJ
一种改进的减少易感性伪影的功能磁共振成像(FMRI)方法被用于测量可卡因吸毒者大脑对急性可卡因注射的血氧水平依赖(BOLD)反应。静脉注射可卡因(20 mg/70 kg)可激活中脑边缘区和中皮质多巴胺能投射区，并呈现暂时性阳性或阴性BOLD反应。这些来自人类可卡因使用者的结果支持了动物模型中的多巴胺能通路与可卡因成瘾的关系。此外，可卡因还诱导了Brodmann区10区(BA10)的前额叶皮质(APFC)和眶前叶皮质(OFC)的分级脑网络的激活。提示多巴胺能通路和分层脑网络可能参与了人脑可卡因成瘾的奖赏过程、联想学习、动机和记忆过程。(C)2005 Elsevier Inc.保留所有权利。
An improved functional MRI (fMRI) method for the reduction of susceptibility artifacts has been utilized to measure blood oxygen level-dependent (BOLD) responses to acute cocaine administration in the human brain of cocaine users. Intravenous administration of cocaine (20 mg/70 kg) activated mesolimbic and mesocortical dopaminergic projection regions and showed temporal positive or negative BOLD responses. These results obtained from human cocaine users supported the involvement of the dopaminergic pathway in cocaine addiction from animal models. In addition, the cocaine administration also induced activations in the hierarchical brain networks in the anterior prefrontal cortex (aPFC) of the Brodmann area 10 (BA10) and orbitofrontal cortex (OFC). It is suggested that the dopaminergic pathways and the hierarchical brain networks may participate in mediating cocaine reward processes, associative learning, motivation, and memory in cocaine addiction in the human brain. (c) 2005 Elsevier Inc. All rights reserved.