CANCER INCIDENCE AMONG SWEDISH BREWERY WORKERS
CANCER INCIDENCE AMONG SWEDISH BREWERY WORKERS
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DOI：
10.1002/ijc.2910450302
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发表时间：
1990-03-15
影响因子：
6.4
通讯作者：
HATSCHEK, T
中科院分区：
文献类型：
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作者：
CARSTENSEN, JM;BYGREN, LO;HATSCHEK, T
为了检查瑞典啤酒厂工人患癌症（特别是直肠癌）的风险，瑞典癌症登记处在 1961-79 年间对 1960 年啤酒厂雇用的 6,230 名工人进行了跟踪调查。使用所有瑞典男性作为参考组，通过出生年份、随访年份和地理区域的标准化计算相对风险 (RR)。总共观察到 712 例新癌症病例，而预期为 570.7 例 (p < 0.001)。多个癌症部位的风险显着增加，例如食管（RR = 2.5，95% 置信区间 (CI) = 1.5-3.8）、直肠（RR = 1.7，CI = 1.3-2.3）、胰腺（RR = 1.7，CI = 1.2-2.3）和肺（RR = 1.4，CI = 1.1-1.7）。肝癌的额外风险几乎是显着的（p = 0.053，RR = 1.7。CI = 1.0-2.8）。结肠癌的风险没有显着增加（RR = 1.2，CI = 0.9-1.5），并且结肠癌与直肠癌的相对风险之间的差异几乎是显着的（p = 0.07）。我们的结果支持这样的假设：大量啤酒消费与直肠癌风险增加相关。
In order to examine the risks of cancer, particularly of rectal cancer, among Swedish brewery workers, 6,230 men employed in the brewery industry in 1960 were followed-up during 1961-79 by the Swedish Cancer Registry. Using all Swedish men as a reference group, relative risks (RR) were computed with standardization for year of birth, year of follow-up, and geographic region. A total of 712 new cases of cancer were observed compared to 570.7 expected (p < 0.001). Significantly increased risks were seen for several cancer sites, e.g. esophagus (RR = 2.5, 95% confidence interval (CI) = 1.5-3.8) rectum (RR = 1.7, CI = 1.3-2.3), pancreas (RR = 1.7, CI = 1.2-2.3), and lung (RR = 1.4, CI = 1.1-1.7). An excess risk of liver cancer was almost significant (p = 0.053, RR = 1.7. CI = 1.0-2.8). The risk of colon cancer was not significantly increased (RR = 1.2, CI = 0.9-1.5), and the difference between the relative risk of colon cancer and that of rectum cancer was nearly significant (p = 0.07). Our results support the hypothesis that high beer consumption is associated with an increased risk of rectal cancer.