Zinc signal: a new player in osteobiology
Zinc signal: a new player in osteobiology
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DOI：
10.1007/s00774-012-0409-6
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发表时间：
2013-03-01
影响因子：
3.3
通讯作者：
Furuichi, Tatsuya
中科院分区：
文献类型：
--
作者：
Fukada, Toshiyuki;Hojyo, Shintaro;Furuichi, Tatsuya
哺乳动物体内锌稳态失调的主要特征是骨骼生成受损，并伴有生长迟缓。然而，决定锌如何控制骨稳态的潜在机制仍有待确定。锌稳态是由锌转运蛋白家族严格控制的。最近的研究表明，锌转运蛋白介导的锌离子（Zn 2+）作为一种信号因子，称为Zn信号，在细胞事件中发挥多种功能，这表明为什么锌对哺乳动物的骨生长和再生具有重要作用。这种观点把重要性的主要机制，锌参与哺乳动物骨内稳态，转移我们的重点锌的作用，从简单的营养素的信号分子，微调细胞内信号事件。
Disturbed zinc (Zn) homeostasis in mammals is mainly characterized by impaired bone generation accompanied with growth retardation. However, the underlying mechanisms that determine how Zn controls bone homeostasis remain to be defined. Zn homeostasis is tightly controlled by Zn transporter families. Recent studies have shown that Zn transporter-mediated Zn ion (Zn2+) behaves as a signaling factor, called Zn signal, that exerts a multiple function in cellular events, showing why Zn has a vital effect on mammalian bone growth and regeneration. This perspective put importance on the principal mechanisms of Zn participation in mammalian bone homeostasis, shifting our focus on the role of Zn from simply a nutrient to a signaling molecule that fine-tunes intracellular signaling events.