Platelet calmodulin levels in adolescent idiopathic scoliosis - Do the levels correlate with curve progression and severity?
Platelet calmodulin levels in adolescent idiopathic scoliosis - Do the levels correlate with curve progression and severity?
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DOI：
10.1097/00007632-200204010-00016
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发表时间：
2002-04-01
期刊：
影响因子：
3
通讯作者：
O'Brien, M
中科院分区：
文献类型：
--
作者：
Lowe, T;Lawellin, D;O'Brien, M
研究设计.这项正在进行的纵向研究评价了脊柱发育不成熟的特发性脊柱侧凸患者同时进行的影像学和血小板钙调素测定。确定血小板钙调素水平是否与曲线进展和严重程度相关。先前的一项研究基于单次钙调素测定和单次X光片，在进行性曲线和较高幅度曲线中确定了较高的钙调素水平。需要一个纵向研究来证明钙调素的关系曲线的变化，随着时间的推移，个别患者在生长期。在这项研究中，对55例不同类型和严重程度的特发性脊柱侧凸患者进行了纵向随访，并进行了系列X线片和血小板钙调素测定。在每次访视时记录每张X线片的Risser征。13例进展期患者钙调素水平均升高（13/13），73例非进展期患者钙调素水平稳定（11/15），大于30度曲线和双结构曲线患者钙调素水平普遍升高。钙调素水平通常在接受支具治疗（14/17）或脊柱融合术（9/10）的患者中降低。血小板钙调蛋白水平似乎与脊柱弯曲的进展和支具或脊柱融合的稳定性密切相关。与非进展性曲线的相关性不一致，有27%不相关。需要更长时间的随访评估和招募更多的患者，以确定钙调蛋白是否可以作为曲线进展的生化标志物，并帮助识别稳定和进展的曲线。
Study Design. This ongoing longitudinal study evaluates simultaneous radiographic and platelet calmodulin determinations for patients with idiopathic scoliosis who are skeletally immature.Objectives. To determine whether platelet calmodulin levels correlate with curve progression and severity.Summary of Background Data. A previous study based on a single calmodulin determination and a single radiograph identified higher calmodulin levels in progressive curves and in higher magnitude curves. A longitudinal study was needed to demonstrate the relation of calmodulin to curve changes for individual patients over time during the growth period.Methods. In this study, 55 patients with idiopathic scoliosis of varying types and severity were followed longitudinally with serial radiographs and platelet calmodulin determinations. A Risser sign was recorded for each radiograph at each visit.Results. Calmodulin levels increased in all the patients with progressive curves (13/13), remained stable in 73 l0 of the patients with nonprogressive curves (11/15), and were higher generally in curves greater than 30 and double structural curves. Calmodulin levels usually decreased in patients undergoing brace treatment (14/17) or spine fusion (9/10).Conclusions. It appears that platelet calmodulin levels correlate closely with curve progression and stabilization by bracing or spine fusion. Correlation with nonprogressive curves was not as consistent, with 27% noncorrelation. Longer follow-up evaluation and enrollment of additional patients will be necessary to determine whether calmodulin may serve as a biochemical marker of curve progression and to help identify stable and progressive curves.