Current management of Wilms' tumor in children
Current management of Wilms' tumor in children
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DOI：
10.1016/j.jpurol.2008.08.007
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发表时间：
2009-02-01
影响因子：
2
通讯作者：
Ritchey, Michael L.
中科院分区：
文献类型：
--
作者：
Ko, Edmund Y.;Ritchey, Michael L.
目的：肾母细胞瘤是儿童最常见的肾脏肿瘤。在过去的几十年里，结果有了显着改善，但重要的治疗问题仍然存在。这些包括分子生物学标记物在对患者进行分层治疗或靶向肿瘤治疗中的作用。我们提出了一个总结这些进展，并概述了目前的治疗肾母细胞瘤。材料和方法：医学文献和所有合作组的研究报告治疗儿童肾母细胞瘤的结果进行了review.Results：总生存率超过90%，大多数肾母细胞瘤患者。然而，横纹肌样瘤和弥漫性间变性患者的结局仍然很差。肾脏保留手术在双侧肿瘤患者中的作用是明确的，但对于单侧肿瘤的儿童，它仍然是defined.Conclusions：目前的协议进行的儿科肿瘤组开始纳入生物学特征，分层治疗的患者。治疗策略继续关注限制治疗的晚期效应，同时保持良好的生存率。需要新的疗法来治疗那些复发率和死亡率仍然很高的高危患者。(C)2008年《儿科泌尿学杂志》。由爱思唯尔有限公司出版。保留所有权利。
Purpose: Wilms' tumor is the most common renal tumor in children. Outcomes have improved dramatically over the past few decades, but important treatment questions remain. These include the role of molecular biologic markers in stratifying patients for therapy or targeting tumors for treatment. We present a summary of these advances and outline the current treatment of Wilm's tumor.Materials and methods: The medical literature and results of all cooperative group studies reporting treatment of children with Wilms' tumor were reviewed.Results: Overall survival exceeds 90% for most patients with nephroblastoma. However, outcomes for patients with rhabdoid tumors and diffuse anaplasia remain poor. The role of renal sparing surgery in patients with bilateral tumors is clear, but for children with unilateral tumors it continues to be defined.Conclusions: Current protocols conducted by pediatric oncology groups are beginning to incorporate biologic features to stratify patients for therapy. Treatment strategies continue to focus on limiting late effects of treatment while maintaining an excellent survival. New therapies are needed to treat the high-risk patients who continue to have high relapse and mortality rates. (C) 2008 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.