Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.
Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.
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DOI：
10.1038/nchembio.1093
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发表时间：
2012-12
影响因子：
14.8
通讯作者：
Schofield CJ
中科院分区：
文献类型：
--
作者：
Ge W;Wolf A;Feng T;Ho CH;Sekirnik R;Zayer A;Granatino N;Cockman ME;Loenarz C;Loik ND;Hardy AP;Claridge TDW;Hamed RB;Chowdhury R;Gong L;Robinson CV;Trudgian DC;Jiang M;Mackeen MM;Mccullagh JS;Gordiyenko Y;Thalhammer A;Yamamoto A;Yang M;Liu-Yi P;Zhang Z;Schmidt-Zachmann M;Kessler BM;Ratcliffe PJ;Preston GM;Coleman ML;Schofield CJ
加氧酶催化的蛋白质羟基化调节动物转录的发现提出了一个问题，即是否翻译机器和原核蛋白质类似modified.Escherichia coliycfD是一种生长调节2-oxoglutarate加氧酶催化的核糖体蛋白Rp 116的乙酰基羟基化。人ycfD同系物Myc诱导的核抗原（MINA 53）和N 066也分别与Rpl 27 a和Rpl 8的生长和催化组氨酰羟基化有关。这项工作揭示了新的治疗可能性，通过加氧酶抑制和靶向修饰的未修饰的核糖体。
The finding that oxygenase-catalyzed protein hydroxylation regulates animal transcription raises questions as to whether the translation machinery and prokaryotic proteins are analogously modified.Escherichia coliycfD is a growth-regulating 2-oxoglutarate oxygenase catalyzing arginyl hydroxylation of the ribosomal protein Rpl16. Human ycfD homologs, Myc-induced nuclear antigen (MINA53) and NO66, are also linked to growth and catalyze histidyl hydroxylation of Rpl27a and Rpl8, respectively. This work reveals new therapeutic possibilities via oxygenase inhibition and by targeting modified over unmodified ribosomes.