Chasing tails in ascidians: developmental insights into the origin and evolution of chordates.
Chasing tails in ascidians: developmental insights into the origin and evolution of chordates.
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海鞘追逐尾巴：对脊索动物起源和进化的发育洞察。
DOI：
10.1016/s0168-9525(00)89106-4
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Jeffery,WR
中科院分区：
文献类型：
--
作者：
Satoh,N;Jeffery,WR
海鞘蝌蚪幼虫被认为是祖先脊索动物的原型。在这里，我们认为最近的研究，蝌蚪幼虫的发展提供了新的见解脊索动物的起源和进化。海鞘幼虫和脊椎动物的脊索似乎是同源结构，这是基于它们的内胚层诱导和Brachyury（T）基因的表达。海鞘幼虫的肌细胞也出现同源的脊椎动物的基础上，他们的表达bHLH肌和肌肉型肌动蛋白基因，虽然它们是指定的细胞质决定因素定位在鸡蛋以及胚胎诱导。对无尾海鞘无尾幼虫的研究发现了Manx基因，该基因可能控制着尾的发育和进化。这些和其他结果支持海鞘蝌蚪原型的祖先脊索动物。
The ascidian tadpole larva is regarded as a prototype of the ancestral chordate. Here we consider recent studies on the development of the tadpole larva that provide new insights into chordate origins and evolution. The notochord of ascidian larvae and vertebrates appear to be homologous structures based on their induction by endoderm and expression of the Brachyury (T) gene. The muscle cells of ascidian larvae also appear homologous to those of vertebrates based on their expression of bHLH myogenic and muscle-type actin genes, although they are specified by cytoplasmic determinants localized in the egg as well as embryonic induction. Studies of the tailless larvae of anural ascidians have resulted in the identification of Manx, a gene that may control tail development and evolution. These and other results support the ascidian tadpole prototype for the ancestral chordate.