Neurotrophic receptor TrkB: Is it a predictor of poor prognosis for carcinoma patients?
Neurotrophic receptor TrkB: Is it a predictor of poor prognosis for carcinoma patients?
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神经营养受体 TrkB：它是癌症患者预后不良的预测因子吗？
DOI：
10.1016/j.mehy.2006.05.038
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发表时间：
2007-01-01
影响因子：
4.7
通讯作者：
Sun, Wensheng
中科院分区：
文献类型：
--
作者：
Han, Lihui;Zhang, Zhiyong;Sun, Wensheng
神经营养受体酪氨酸激酶TrkB与其高亲和力配体脑源性神经营养因子（brain-derived neurotrophic factor，BDNF）结合，在神经系统发育、神经元存活、分化和维持中发挥重要作用。然而，越来越多的证据提示TrkB信号通路可能参与多种人类肿瘤的发生、发展和转移。TrkB的过表达往往与这些恶性肿瘤的发生、血管生成和耐药性相关，并对这些预后不良的肿瘤的转移和侵袭表型有重要贡献。TrkB在恶性肿瘤中的重要作用不仅来自于实体瘤如新母细胞瘤、胰腺癌、肾母细胞瘤和肝癌，而且来自于血液系统恶性肿瘤如霍奇金淋巴瘤和多发性骨髓瘤。综上所述，TrkB除了参与神经系统的发育和功能外，还可能在肿瘤的发生和转移中发挥作用，但仍有待于进一步研究和证实。近年来的研究表明，TrkB不仅是肿瘤发生和转移的标志物，也是肿瘤发生和转移的介导因子，因此TrkB有可能成为肿瘤治疗的一个有价值的靶点，特别是对于预后不良的转移性肿瘤。(c)2006爱思唯尔有限公司保留所有权利。
The neurotrophic receptor tyrosine kinase TrkB, white binding its high affinity ligand brain-derived neurotrophic factor (BDNF), will play an essential rote for nervous system development, neuronal survival, differentiation, and maintenance. However, accumulating evidences implies that TrkB signal pathway may also be involved in a variety of human cancers, in which TrkB is likely to play a rote in initiation and metastasis of carcinomas. Overexpression of TrkB is often correlated with the tumorigenesis, angiogenesis and drug resistance in these malignancies, contributing significantly to the metastasis and aggressive phenotype of these poor prognosis tumors. The evidences to show the significant contribution of TrkB to malignancy not only came from solid tumors such as neoblastoma, pancreas cancer, Wilm's tumor and hepatocarcinoma, but also came from haematological malignancies such as Hodgkin tymphoma and Multiple myeloma. In summary, besides its rote in development and function of nervous system, TrkB is likely to also play a role in initiation and metastasis of carcinoma although it still remains to be further investigated and confirmed. Emerging data have suggested that TrkB may be a mediator as well as a marker of carcinogenesis and metastasis, therefore TrkB may be used as a valuable target for cancer therapy especially for the metastatic tumors with poor prognosis. (c) 2006 Elsevier Ltd. All rights reserved.