Mid-treatment Ultrasound Descriptors as Qualitative Imaging Biomarkers of Pathologic Complete Response in Patients with Triple-Negative Breast Cancer.
Mid-treatment Ultrasound Descriptors as Qualitative Imaging Biomarkers of Pathologic Complete Response in Patients with Triple-Negative Breast Cancer.
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DOI：
10.1016/j.ultrasmedbio.2022.01.018
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发表时间：
2022-06
影响因子：
2.9
通讯作者：
Yang, Wei T.
中科院分区：
文献类型：
--
作者：
Candelaria, Rosalind P.;Adrada, Beatriz E.;Lane, Deanna L.;Rauch, Gaiane M.;Moulder, Stacy L.;Thompson, Alastair M.;Bassett, Roland L.;Arribas, Elsa M.;Le-Petross, Huong T.;Leung, Jessica W. T.;Spak, David A.;Ravenberg, Elizabeth E.;White, Jason B.;Valero, Vicente;Yang, Wei T.
该研究旨在研究治疗中期乳腺肿瘤超声特征，这些特征可能预测三阴性乳腺癌（TNBC）患者的最终病理完全缓解（pCR）;具体而言，我们检查了pCR与两个参数之间的相关性：1）肿瘤缓解模式和2）肿瘤外观。超声检查在治疗中期进行，定义为完成四个周期的蒽环类化疗和接受紫杉烷类化疗之前。在对病理结果不知情的情况下进行共识成像审查（即，pCR/非pCR）。肿瘤缓解模式描述为“完全”、“同心”、“碎片化”、“稳定”或“进展”。肿瘤外观被指定为“肿块”、“结构变形”、“扁平肿瘤床”或“仅夹”。对144例患者的单变量和多变量回归分析显示，治疗中期缓解模式与pCR之间存在显著相关性（分别为P=0.0348和P=0.0173），完全缓解模式和同心缓解模式比其他模式更有可能实现pCR。单变量和多变量回归分析进一步显示治疗中期肿瘤外观与pCR之间存在显著相关性（两者均P<0.0001），与其他外观相比，持续出现肿块不太可能实现pCR。总之，我们的研究证明了pCR与肿瘤反应模式和肿瘤外观之间的强相关性，从而表明这些参数具有作为TNBC患者中pCR的定性成像生物标志物的潜力。
The study aimed to investigate midtreatment breast tumor ultrasound characteristics that may predict eventual pathologic complete response (pCR) in triple-negative breast cancer (TNBC) patients; specifically, we examined associations between pCR and two parameters: 1) tumor response pattern and 2) tumor appearance. Ultrasound was performed at midtreatment, defined as the completion of four cycles of anthracycline-based chemotherapy and before receiving taxane-based chemotherapy. Consensus imaging review was performed while blinded to pathology results (i.e., pCR/non-pCR) from surgery. Tumor response pattern was described as “complete,” “concentric,” “fragmented,” “stable,” or “progression.” Tumor appearance was designated as “mass,” “architectural distortion,” “flat tumor bed,” or “clip only.” Univariate and multivariate regression analyses of 144 patients showed significant associations between midtreatment response pattern and pCR (P=0.0348 and P=0.0173, respectively) with complete and concentric response patterns more likely to achieve pCR than other patterns. Univariate and multivariate regression analyses further showed significant associations between midtreatment tumor appearance and pCR (P<0.0001 for both) with persistent appearance of mass less likely than other appearances to achieve pCR. To conclude, our study demonstrated strong associations between pCR and both tumor response pattern and tumor appearance, thereby suggesting that these parameters have potential as qualitative imaging biomarkers of pCR in TNBC patients.
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DOI：
10.1186/s13058-018-0950-x
发表时间：
2018-04-18
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Goorts B;Dreuning KMA;Houwers JB;Kooreman LFS;Boerma EG;Mann RM;Lobbes MBI;Smidt ML
通讯作者：
Smidt ML
影响因子：
3.9
作者：
van der Noordaa, M. E. M.;van Duijnhoven, F. H.;Peeters, M. T. F. D. Vrancken
通讯作者：
Peeters, M. T. F. D. Vrancken
影响因子：
3.7
作者：
Rauch, Gaiane M.;Kuerer, Henry M.;Yang, Wei T.
通讯作者：
Yang, Wei T.
影响因子：
3.8
作者：
Gounaris, I.;Provenzano, E.;Sinnatamby, R.
通讯作者：
Sinnatamby, R.
影响因子：
3.9
作者：
Baumgartner, Annina;Tausch, Christoph;Baege, Astrid
通讯作者：
Baege, Astrid