ATM and ATR - Components of an integrated circuit
ATM and ATR - Components of an integrated circuit
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DOI：
10.4161/cc.6.4.3886
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发表时间：
2007-02-15
期刊：
影响因子：
4.3
通讯作者：
Bunz, Fred
中科院分区：
文献类型：
--
作者：
Hurley, Paula J.;Bunz, Fred
磷脂酰肌醇3-激酶样激酶(PIKKs)、ATM和ATR激活一个复杂的信号网络，以响应不同形式的DNA损伤。这些信号分子的最初特征集中在每个信号分子在回应特定类型的DNA损伤时所起的单独作用。最近，关于DNA损伤信号网络的更完整的观点已经出现。ATM和ATR激活的信号通路曾经看起来是平行的，但新的发现表明，这种细胞电路是高度相互连接的。ATM和ATR之间的通信使细胞能够通过协调的、高度调制的输出对DNA链断裂和DNA合成抑制做出反应。在这篇文章中，我们集中在几个新的发展，让我们深入了解在DNA损伤和复制过程中出现的各种信号的综合处理。
The phosphatidylinositol 3-kinase-like kinases (PIKKs) ATM and ATR activate a complex signaling network in response to diverse forms of DNA damage. Initial characterization of these signaling molecules focused on the individual role that each plays in response to specific types of DNA lesions. Recently, a more integrated view of the DNA-damage signaling network has emerged. ATM-and ATR-activated signaling pathways once appeared parallel, but new findings suggest that this cellular circuitry is highly interconnected. Communication between ATM and ATR enables the cell to respond to DNA strand breaks and inhibition of DNA synthesis with coordinated, highly modulated outputs. In this article, we focus on several new developments that give insight into the integrated processing of diverse signals that arise during the damage and replication of DNA.