Novel Thermosensitive Nano-Micelles from Triblock Copolymer for Drug Delivery
Novel Thermosensitive Nano-Micelles from Triblock Copolymer for Drug Delivery
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DOI：
10.1166/jbn.2009.1036
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发表时间：
2009-06-01
影响因子：
2.9
通讯作者：
Li, Jun
中科院分区：
文献类型：
--
作者：
Liu, Peng;Wang, Bochu;Li, Jun
研究了以聚（D， l -丙交酯-共乙醇酸酯）-b-聚（乙二醇）-b-聚（D， l -丙交酯-共乙醇酸酯）（PLGA-PEG-PLGA）为载体的新型热敏纳米胶束。以芘为荧光探针，采用荧光光谱法测定了该共聚物在水溶液中的临界胶束浓度为2.34 μ g/ml。通过光学透射率法测定了该共聚物在蒸馏水中的下临界溶解温度（LCST）， LCST随聚合物浓度的变化在35 ~ 55℃之间变化。以对乙酰氨基酚为模型药物，采用溶剂蒸发法制备纳米胶束。与游离药物相比，对乙酰氨基酚在体外的释放表现出持续的模式，当温度高于LCST时，对乙酰氨基酚的释放率明显较高。研究表明，由PLGA-PEG-PLGA制成的纳米胶束可以作为肿瘤特殊药物递送的理想候选载体。
Novel thermosensitive nano-micelles, based on Poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA), as carriers for drug delivery were researched. The critical micelle concentration of the copolymer in aqueous solution was determined to be 2.34 mu g/ml by fluorescence spectroscopy using pyrene as a fluorescence probe. The lower critical solution temperature (LCST) of the copolymer was measured in distilled water by optical transmittance, and the LCST was varied from 35 to 55 degrees C depending on polymer concentration. Acetaminophen as a model drug was loaded in nano-micelles by solvent evaporation method. In vitro acetaminophen release from micelles showed a sustained modality compared with the free drug as a control, and an obviously high release rate when temperature was increased above LCST The studies showed that nano-micelles made from PLGA-PEG-PLGA could be ideal candidate carriers for tumor-special drug delivery.