Sympathetic and parasympathetic regulation of cystatin S gene expression.
Sympathetic and parasympathetic regulation of cystatin S gene expression.
复制标题
半胱氨酸蛋白酶抑制剂 S 基因表达的交感神经和副交感神经调节。
DOI：
10.1016/s0024-3205(01)01379-0
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发表时间：
2001
期刊：
影响因子：
6.1
通讯作者：
Yu,WH
中科院分区：
文献类型：
--
作者：
Shaw,PA;Yu,WH
植物神经系统在唾液腺的分化和生长以及唾液特异性基因的表达中起着调节作用。半胱氨酸蛋白酶抑制剂S是半胱氨酸蛋白酶抑制剂超家族中进化上保守的家族2的成员，在发育过程中在大鼠的下颌下腺和腮腺中表达，在成年大鼠中可被β-肾上腺素能激动剂异丙肾上腺素（IPR）诱导。先前显示，单侧交感神经切除术或双侧副交感神经切除术减少IPR诱导的胱抑素S表达。目前的实验表明，IPR诱导的半胱氨酸蛋白酶抑制剂S基因表达的颌下腺减少，早在3天后，双侧去神经支配的两个分支的自主神经系统。这种减少几乎等于单独的交感神经切除术或副交感神经切除术的减少，表明交感神经和副交感神经纤维中的因子是IPR诱导的胱抑素S基因表达同时需要的。
The autonomic nervous system plays a regulatory role in the differentiation and growth of salivary glands, and in the expression of salivary specific genes. Cystatin S, a member of the evolutionarily conserved family 2 of the cysteine proteinase inhibitor superfamily, expressed in submandibular and parotid glands of rats during development, can be induced in adults by the β-adrenergic agonist isopreterenol (IPR). It was shown previously that unilateral sympathectomy or bilateral parasympathectomy reduces IPR-induced cystatin S expression. The present experiments demonstrate that IPR-induced cystatin S gene expression in submandibular glands is reduced as early as 3 days post bilateral denervation of both branches of the autonomic nervous system. The reduction is nearly equal to that of either sympathectomy or parasympathectomy alone, suggesting that factor(s) in both sympathetic and parasympathetic fibers are simultaneously required for IPR-induced cystatin S gene expression.