Persistent Infection with West Nile Virus Years after Initial Infection
Persistent Infection with West Nile Virus Years after Initial Infection
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DOI：
10.1086/648731
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发表时间：
2010-01-01
影响因子：
6.4
通讯作者：
Fisher-Hoch, Susan
中科院分区：
文献类型：
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作者：
Murray, Kristy;Walker, Christopher;Fisher-Hoch, Susan
从感染后573-2452天（1.6-6.7年）的25例恢复期患者的尿样中，有5例（20%）检出西尼罗河病毒RNA。测序的5个扩增子中的4个显示与WNV NY 99株的同源性>99%。这些研究结果表明，感染西尼罗河病毒后出现慢性症状的个体可能在数年内持续肾脏感染。
West Nile virus (WNV) RNA was demonstrated in 5 (20%) of 25 urine samples collected from convalescent patients 573-2452 days (1.6-6.7 years) after WNV infection. Four of the 5 amplicons sequenced showed >99% homology to the WNV NY99 strain. These findings show that individuals with chronic symptoms after WNV infection may have persistent renal infection over several years.