Complete Blood Count Alterations of COVID-19 Patients in Riyadh, Kingdom of Saudi Arabia
Complete Blood Count Alterations of COVID-19 Patients in Riyadh, Kingdom of Saudi Arabia
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DOI：
10.1155/2022/6529641
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发表时间：
2022-01-31
影响因子：
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通讯作者：
Mills, Jeremy
中科院分区：
文献类型：
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作者：
Elderdery, Abozer Y.;Elkhalifa, Ahmed M. E.;Mills, Jeremy
本研究旨在评估确诊阳性患者中冠状病毒疾病19（COVID-19）与主要全血细胞计数（CBC）参数之间的相关性。在一项回顾性横断面研究中，随机选择了384例在利雅得沙特国王医疗城住院的确诊COVID-19患者档案作为血液学参数的研究组，另外选择了384例无任何可能影响血液学特征的疾病史的非COVID-19患者档案作为对照组。对照组的性别、年龄、民族与研究组相匹配。与阴性患者相比，COVID-19阳性患者的贫血和血小板减少症患病率显著较高。然而，阳性病例中贫血的可能性为3.4倍，白细胞减少的可能性约为5.3倍，而白细胞减少的患病率在两组之间无统计学意义。然而，两组之间的平均细胞体积（MCV）、总白色血细胞（WBC）计数、淋巴细胞计数和嗜碱性粒细胞计数中位值无显著差异。在严重阳性病例中，贫血和血小板减少症可能高度发展，因此，建议进一步研究以验证这些结果。
This study is aimed at evaluating the association between Coronavirus disease 19 (COVID-19) and the primary complete blood count (CBC) parameters in confirmed positive patients. In a retrospective cross-sectional study, 384 files of patients with confirmed COVID-19 diagnosis hospitalized at King Saud Medical City, Riyadh, were chosen randomly as a study group for hematological parameters, with another 384 non-COVID-19 files of patients without history of any disease which could influence the hematological profile were selected as a control group. The gender, age, and nationality of the control group were matched with those of the study group. Anemia and thrombocytopenia prevalence was significantly higher in COVID-19 positive patients compared with negative. However, the positive cases were 3.4 times more likely to be anemic and approximately 5.3 times as likely to be thrombocytopenic, while the prevalence of leukopenia showed no statistical significance between the two groups. However, the Mean Cell Volume (MCV), Total White Blood Cell (WBC) count, lymphocyte count, and basophil count median values showed a nonsignificant difference between the two groups. Anemia and thrombocytopenia may be highly developed in severe positive cases, and therefore, further studies are recommended to validate these findings.