Successful treatment of calciphylaxis with intravenous sodium thiosulfate
Successful treatment of calciphylaxis with intravenous sodium thiosulfate
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DOI：
10.1053/j.ajkd.2004.03.018
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发表时间：
2004-06-01
影响因子：
13.2
通讯作者：
Spector, DA
中科院分区：
文献类型：
--
作者：
Cicone, JS;Petronis, JB;Spector, DA
钙化防御是肾衰竭的一种可怕的并发症，其特征是结节性皮下钙化和疼痛性组织坏死，通常导致溃疡、继发感染和高死亡率。描述了一名接受连续不卧床腹膜透析的女性的病例，该女性具有典型的钙防御临床表现，经 X 射线和锝扫描结果证实。对常规治疗无反应后，开始每周 3 次静脉注射硫代硫酸钠治疗，她的体征和症状得到了快速而显着的缓解，锝扫描也得到了改善。长期治疗的耐受性良好，没有严重的副作用，并且伴随着持续的临床改善。
Calciphylaxis is a dreaded complication of renal failure characterized by nodular subcutaneous calcification and painful tissue necrosis often leading to ulceration, secondary infection, and high mortality rates. The case of a woman receiving continuous ambulatory peritoneal dialysis who had a typical clinical presentation of calciphylaxis confirmed by x-ray and technetium scan findings is described. After nonresponse to conventional therapy, treatment with intravenous sodium thiosulfate 3 times weekly was begun, and she had rapid and dramatic relief of signs and symptoms and improvement of technetium scans. Prolonged treatment was well tolerated without serious side effects and accompanied by continued clinical improvement.