Ferumoxytol-Enhanced Cardiac Magnetic Resonance Angiography and 4D Flow: Safety and Utility in Pediatric and Adult Congenital Heart Disease.
Ferumoxytol-Enhanced Cardiac Magnetic Resonance Angiography and 4D Flow: Safety and Utility in Pediatric and Adult Congenital Heart Disease.
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DOI：
10.3390/children9121810
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发表时间：
2022-11-24
期刊：
影响因子：
2.4
通讯作者：
Nguyen, Kim-Lien
中科院分区：
文献类型：
--
作者：
Renella, Pierangelo;Li, Jennifer;Prosper, Ashley E.;Finn, J. Paul;Nguyen, Kim-Lien
关键词：
心脏磁共振成像和血管造影在儿童和成人先天性心脏病患者的诊断评估和随访中具有至关重要的作用。虽然高级成像研究所需的大部分信息可以通过标准钆增强磁共振成像提供，但精确的注射时间、长扫描时间、复杂的成像方案以及对小结构成像的需要的局限性限制了这种方式的更广泛使用。最近阿魏木醇在标签外诊断使用的经验有助于减轻这些障碍。阿魏木糖醇是一种超小型超顺磁性氧化铁纳米颗粒，经美国FDA批准用于静脉治疗贫血，具有长血池停留时间和高弛豫性。一旦被巨噬细胞代谢，铁核被纳入网状内皮系统。在本文中，我们旨在总结阿魏木糖醇增强心血管磁共振成像和血管造影的发展，并强调其在先天性心脏病中的许多应用。
Cardiac magnetic resonance imaging and angiography have a crucial role in the diagnostic evaluation and follow up of pediatric and adult patients with congenital heart disease. Although much of the information required of advanced imaging studies can be provided by standard gadolinium-enhanced magnetic resonance imaging, the limitations of precise bolus timing, long scan duration, complex imaging protocols, and the need to image small structures limit more widespread use of this modality. Recent experience with off-label diagnostic use of ferumoxytol has helped to mitigate some of these barriers. Approved by the U.S. FDA for intravenous treatment of anemia, ferumoxytol is an ultrasmall superparamagnetic iron oxide nanoparticle that has a long blood pool residence time and high relaxivity. Once metabolized by macrophages, the iron core is incorporated into the reticuloendothelial system. In this work, we aim to summarize the evolution of ferumoxytol-enhanced cardiovascular magnetic resonance imaging and angiography and highlight its many applications for congenital heart disease.
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