Antral nodularity and positive CagA serology are distinct and relevant markers of severe gastric inflammation in children with Helicobacter pylori infection
Antral nodularity and positive CagA serology are distinct and relevant markers of severe gastric inflammation in children with Helicobacter pylori infection
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DOI：
10.1046/j.1523-5378.2002.00055.x
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发表时间：
2002-02-01
期刊：
影响因子：
4.4
通讯作者：
Pallone, F
中科院分区：
文献类型：
--
作者：
Luzza, F;Pensabene, L;Pallone, F
背景本研究的目的是评估是否胃窦结节和血清IgG抗体CagA的内镜检查结果与更高级别的胃inflammation.Materials和方法。重新分析了先前发表的两项试验的综合数据。153名接受胃镜检查的儿童（中位年龄9.5岁）被纳入研究。从胃窦和胃体取活检标本，以评估幽门螺杆菌状态、胃炎评分和淋巴滤泡。在内窥镜检查中，发现胃窦结节。检测血清中抗CagA的IgG抗体。在77例有H证据的儿童中，32例（41.5%）发现胃窦结节（nod+）和CagA血清学阳性（CagA+）。幽门感染交叉表型显示nod+/CagA+20例（26%），nod+/CagA-12例（15.5%），nod-/CagA +12例（15.5%），nod-/CagA-33例（43%）。nod-/CagA-儿童的Gastrointestinal评分显著低于nod+/CagA-（p = 0.004）、nod-/CagA+（p = 0.002）和nod+/CagA+（p
Background. The aim of this study was to assess whether the endoscopic finding of antral nodularity and serum IgG antibodies to CagA are associated with higher grades of gastric inflammation.Materials and methods. The comprehensive data of two previously published trials were reanalysed. One hundred and fifty-three children (median age 9.5 years) who underwent gastroscopy were included. Biopsy, specimens from the antrum and corpus were taken to assess Helicobacter pylori status, gastritis score and lymphoid follicles. During endoscopy, antral nodularity was noted. Serum samples were assayed for IgG antibodies to CagA.Results. The presence of antral nodularity (nod+) and positive CagA serology (CagA+) were each found in 32 of the 77 (41.5%) children who had evidence of H. pylori infection. Crosstabulation showed that 20 children (26%) were nod+/CagA+, 12 (15.5%) nod+/CagA-, 12 (15.5%) nod-/CagA+ and 33 (43%) nod-/CagA-. Gastritis score was significantly lower in nod-/CagA-children than in nod+/CagA- (p =.004), nod-/CagA+ (p =.002) and nod+/CagA+ (p