RELATIONSHIP OF SATIETY TO POSTPRANDIAL GLYCEMIC, INSULIN AND CHOLECYSTOKININ RESPONSES
RELATIONSHIP OF SATIETY TO POSTPRANDIAL GLYCEMIC, INSULIN AND CHOLECYSTOKININ RESPONSES
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DOI：
10.1016/0195-6663(92)90190-h
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发表时间：
1992-04-01
期刊：
影响因子：
5.4
通讯作者：
HANSKY, J
中科院分区：
文献类型：
--
作者：
HOLT, S;BRAND, J;HANSKY, J
The effect of plasma glucose on satiety and the capacity of carbohydrates to stimulate cholecystokinin (CCK) remain unclear. The aim of this study was to test the hypotyhesis that the magnitude of the postprandial plasma glucose and insulin response is inversely related to the CCK response and to subjective satiety. Seven healthy, male volunteers consumed equal carbohydrate portions (0.5 g/kg body weight) of six test meals (Rice Bubbles®, Sustain®, Vita-Brits®, All-Bran®, porridge and white bread) in random order after an overnight fast. An egg and bacon meal was consumed as a non-carbohydrate control providing 0.5 g protein/kg body weight. Serum CCK, plasma glucose and insulin and subjective satiety (measured by a rating scale) were assessed over 3h and quantified using the glycaemic index (GI), insulin index (II), the peak satiety score and area under the incremental curve (AUC). The observed GIs (mean ± SE) ranged from 42.5 ± 2.6 for All-Bran to 116.2 ± 11.4 for Rice Bubbles, using white bread as the reference food (GI = 100). Peak satiety scores varied eightfold from 0.21 ± 0.4 for Sustain to 1.64 ± 0.4 for All-Bran. Significant inverse relationships were observed between the peak satiety score and both the glycaemic and insulin index of the seven meals (r= − 0.916,p< 0.001 andr= − 0.926,p< 0.001). A direct relationship was observed between satiety (AUC) and the CCK response (AUC) (r= 0.73p< 0.01). The results suggest that glycaemic and insulin responses to carbohydrate foods are inversely proportional to the CCK response and satiety.
