Expression of Toll-like receptors by neonatal leukocytes
Expression of Toll-like receptors by neonatal leukocytes
复制标题
DOI：
10.1111/j.1399-3038.2010.01091.x
复制
发表时间：
2011-03-01
影响因子：
4.4
通讯作者：
Nicholson, Ian C.
中科院分区：
文献类型：
--
作者：
Dasari, Pallave;Zola, Heddy;Nicholson, Ian C.
新生儿的免疫系统发育不良，这增加了新生儿感染的易感性。对于新生儿来说，为了有效地对抗感染，他们首先需要识别病原体的存在。Toll样受体(Toll-like Receptor，TLR)是一类模式识别受体家族，可提醒宿主注意入侵病原体的存在。为了确定白细胞表达TLR的差异是否补偿了新生儿免疫不成熟，比较了成人和新生儿单核细胞和T淋巴细胞TLR的表达。用抗体流式细胞仪检测单核细胞和T淋巴细胞TLR1、TLR2、TLR3、TLR4、TLR8和TLR9的表达。检测成人和新生儿单核细胞TLR1、TLR2、TLR3、TLR4、TLR8和TLR9的表达。检测成人和新生儿T淋巴细胞TLR2、TLR3、TLR4、TLR8和TLR9的表达。新生儿的单核细胞和T淋巴细胞能够像成年人一样，通过TLR识别病原体的存在。
The immune system of neonates is poorly developed; this increases the susceptibility of neonates to infection. For neonates to counter infection effectively, they first need to recognize the presence of pathogens. Toll-like receptors (TLR) are a family of pattern recognition receptors that alert the host to the presence of invading pathogens. To determine whether differences in TLR expression by leukocytes compensate for immunologic immaturity in neonates, TLR expression by monocytes and T lymphocytes from adults and neonates was compared. Expression of TLR1, TLR2, TLR3, TLR4, TLR8 and TLR9 by monocytes and T lymphocytes was detected with antibodies by flow cytometry. TLR1, TLR2, TLR3, TLR4, TLR8 and TLR9 expression by monocytes was detected in adults and neonates. TLR2, TLR3, TLR4, TLR8 and TLR9 expression by T lymphocytes was detected in adults and neonates. Monocytes and T lymphocytes from neonates are capable, like adults, of recognizing the presence of pathogens through TLR.