Two hypotheses on the feedback regulation of pancreatic enzyme secretion
Two hypotheses on the feedback regulation of pancreatic enzyme secretion
复制标题
胰酶分泌反馈调节的两种假说
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
K. Iwai
中科院分区：
文献类型：
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作者：
T. Fushiki;K. Iwai
We review the mechanisms underlying the feedback regulation of pancreatic enzyme secretion in response to a meal. Pancreatic enzyme secretion in the rat and pig is known to be regulated by a negative feedback mechanism mediated by intestinal trypsin and chymo‐trypsin. Such a mechanism has recently been noted in humans. The presence of these enzymes in the small intestine suppresses pancreatic enzyme secretion, whereas their removal increases it. Two novel peptides have been proposed to account for the stimulation of pancreatic enzyme secretion in response to feeding trypsin inhibitor. One was assumed to be present in rat pancreatic juice and the other to be spontaneously secreted from the rat small intestine. In either case, trypsin and trypsin inhibitors do not directly interact with the luminal surface of the small intestine, but their actions are mediated by a trypsin‐sensitive, cholecystokinin‐releasing peptide. This is a novel explanation of the well‐recognized stimulation of pancreatic enzyme secretion in response to dietary protein intake.— Fushiki, T.; Iwai, K. Two hypotheses on the feedback regulation of pancreatic enzyme secretion. FASEB J. 3: 121‐126; 1989.
