Correlations between mercury concentrations in umbilical cord tissue and other biomarkers of fetal exposure to methylmercury in the Japanese population
Correlations between mercury concentrations in umbilical cord tissue and other biomarkers of fetal exposure to methylmercury in the Japanese population
复制标题
DOI：
10.1016/j.envres.2006.03.004
复制
发表时间：
2007-01-01
影响因子：
8.3
通讯作者：
Akagi, Hirokatsu
中科院分区：
文献类型：
--
作者：
Sakamoto, Mineshi;Kaneoka, Tsuyoshi;Akagi, Hirokatsu
甲基汞（MeHg）是通过食用鱼类影响人类的最危险物质之一，胎儿是已知的最易受影响的群体。在这项研究中，我们的目的是研究脐带组织和其他组织之间总汞（THg）和甲基汞浓度的关系，作为胎儿暴露于甲基汞的生物标志物。在日本的三个地区，对马岛、福冈市和东京都的胜葛区，总共收集了116个配对样本。测定毛发中THg含量，测定脐带血、母体血和脐带血中THg和MeHg含量。各地区组织间汞浓度关系相似。因此，我们使用所有样本分析关系。脐带组织、脐带血和母体血液中汞含量超过90%为甲基汞。脐带血中THg和MeHg的含量约为母体血的两倍。脐带组织中THg和MeHg有很强的相关性。脐带组织THg和MeHg与脐带血汞有很强的相关性，脐带血汞被认为是胎儿MeHg暴露的最佳生物标志物。本研究结果表明，脐带组织THg和MeHg作为胎儿分娩时MeHg暴露的生物标志物具有重要意义。(c) 2006爱思唯尔公司版权所有。
Methylmercury (MeHg) is one of the most risky substances to affect humans through fish consumption, and the fetus is known to be in the most susceptible group. Our objective in this study is to examine the relationships of total mercury (THg) and MeHg concentrations between umbilical cord tissue and other tissues as biomarkers of fetal exposure to MeHg in the Japanese population. In total, 116 paired samples were collected in three Japanese districts, the Tsushima Islands, Fukuoka City, and Katsushika ward of metropolitan Tokyo. THg was measured for hair and THg and MeHg were measured in cord tissues, maternal blood, and cord blood. The relationships among tissues in Hg concentrations were similar among districts. Therefore, we analyzed the relationships using all the samples. More than 90% of Hg in cord tissue, cord blood, and maternal blood was MeHg. THg and MeHg in cord blood was about two times higher than in maternal blood. A strong correlation was found between THg and MeHg in cord tissue. The cord tissue THg and MeHg showed a strong correlation with cord blood Hg, which is recognized as the best biomarker for fetal exposure to MeHg. The findings of this study indicate the significance of cord tissue THg and MeHg as biomarkers for fetal exposure to MeHg at parturition. (c) 2006 Elsevier Inc. All rights reserved.