Effects of a peer advocacy intervention on cervical cancer screening among social network members: results of a randomized controlled trial in Uganda.
Effects of a peer advocacy intervention on cervical cancer screening among social network members: results of a randomized controlled trial in Uganda.
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DOI：
10.1007/s10865-023-00418-6
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发表时间：
2023-12
影响因子：
3.1
通讯作者：
Wanyenze, Rhoda K
中科院分区：
文献类型：
--
作者：
Wagner, Glenn J;Matovu, Joseph K B;Juncker, Margrethe;Namisango, Eve;Bouskill, Kathryn;Nakami, Sylvia;Beyeza-Kashesya, Jolly;Luyirika, Emmanuel;Bogart, Laura M;Green, Harold D;Wanyenze, Rhoda K
宫颈癌（CC）是乌干达妇女中最常见的癌症，但终身CC筛查率低至5%。培训那些筛查过CC的妇女参与同伴宣传，可以增加社交网络对CC筛查的吸收。我们进行了一项随机对照试验，同行促进，手动，7届小组干预，培训妇女从事CC预防宣传。40名妇女最近筛选CC（指数参与者）登记，并被分配到接受干预（n = 20）或等待名单控制（n = 20）。每个指数被要求招募最多三名女性社交网络成员（改变）谁没有被筛选CC（n = 103登记改变）。在基线和第6个月随访时对所有指数和其他参与者进行评估。除一名（n = 39; 98%）指数参与者和98名（95%）其他参与者外，所有参与者均完成了第6个月评估。在控制基线结局指标和人口统计学协变量的多变量回归模型中，与对照改变相比，干预改变更有可能在第6个月时筛查CC [67% vs. 16%;校正OR（95%CI）= 12.13（4.07，36.16）]。数据还显示，与对照组相比，第6个月时干预组的指数和改变参与者对CC预防宣传的参与显着增加。干预措施是非常有效的，增加CC筛选社会网络成员之间的摄取，并参与CC预防宣传不仅干预受援国，但也宣传的目标，这表明CC知识的广泛传播的潜力。试验注册。NIH临床试验注册NCT 04960748（clinicaltrials.gov）。
Cervical cancer (CC) is the most common cancer among women in Uganda, yet lifetime CC screening is as low as 5%. Training women who have screened for CC to engage in peer advocacy could increase uptake of CC screening in social networks. We conducted a randomized controlled trial of a peer-facilitated, manualized, 7-session group intervention to train women to engage in CC prevention advocacy. Forty women recently screened for CC (index participants) enrolled and were assigned to receive the intervention (n = 20) or wait-list control (n = 20). Each index was asked to recruit up to three female social network members (alters) who had not been screened for CC (n = 103 enrolled alters). All index and alter participants were assessed at baseline and month-6 follow-up. All but one (n = 39; 98%) index and 98 (95%) alter participants completed the month 6 assessment. In multivariate regression models controlling for baseline outcome measures and demographic covariates, intervention alters were more likely to have been screened for CC at month 6 [67% vs. 16%; adjusted OR (95% CI) = 12.13 (4.07, 36.16)], compared to control alters. Data also revealed significant increased engagement in CC prevention advocacy, among both index and alter participants in the intervention group at month 6, compared to the control group. The intervention was highly effective in increasing CC screening uptake among social network members, and engagement in CC prevention advocacy among not only intervention recipients, but also targets of advocacy, suggesting the potential for wide dissemination of CC knowledge. Trial Registration. NIH Clinical Trial Registry NCT04960748 (clinicaltrials.gov).