Environmental Programming of Susceptibility and Resilience to Stress in Adulthood in Male Mice
Environmental Programming of Susceptibility and Resilience to Stress in Adulthood in Male Mice
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DOI：
10.3389/fnbeh.2019.00040
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发表时间：
2019-03-01
影响因子：
3
通讯作者：
Bagot, Rosemary C.
中科院分区：
文献类型：
--
作者：
Pena, Catherine Jensen;Nestler, Eric J.;Bagot, Rosemary C.
流行病学证据表明，早期生活逆境是情绪障碍发展的一个重要风险因素。许多证据表明，早期生活经历在成年后对压力的敏感性方面发挥了作用，在较小程度上，对压力的恢复力也发挥了作用。虽然这些现象的许多模型存在于文献中，但结果往往相互矛盾，缺乏对多个模型的系统比较。在这里，我们比较了9个操作的影响，跨越出生后早期通过振作青少年时期，无论是在基线和暴露于慢性社会失败的压力，在成年期，在雄性小鼠。通过在三种常用的抑郁和焦虑样行为的测量中应用严格的标准，我们确定了增加成年后对后续压力的易感性的操纵，以及减轻成年压力的有害后果的其他亲弹性操纵。我们的研究结果指出了早期生活压力的重要性，并为未来的研究提供了基础，以探索早期生活环境变化所带来的风险和弹性的神经生物学机制。
Epidemiological evidence identifies early life adversity as a significant risk factor for the development of mood disorders. Much evidence points to the role of early life experience in susceptibility and, to a lesser extent, resilience, to stress in adulthood. While many models of these phenomena exist in the literature, results are often conflicting and a systematic comparison of multiple models is lacking. Here, we compare effects of nine manipulations spanning the early postnatal through perk adolescent periods, both at baseline and following exposure to chronic social defeat stress in adulthood, in male mice. By applying rigorous criteria across three commonly used measures of depression- and anxiety-like behavior, we identify manipulations that increase susceptibility to subsequent stress in adulthood and other pro-resilient manipulations that mitigate the deleterious consequences of adult stress. Our findings point to the importance of timing of early life stress and provide the foundation for future studies to probe the neurobiological mechanisms of risk and resilience conferred by variation in the early life environment.