Multimodal cancer therapy involving oncolytic newcastle disease virus, autologous immune cells, and bi-specific antibodies.
Multimodal cancer therapy involving oncolytic newcastle disease virus, autologous immune cells, and bi-specific antibodies.
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DOI：
10.3389/fonc.2014.00224
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发表时间：
2014
影响因子：
4.7
通讯作者：
Fournier P
中科院分区：
文献类型：
--
作者：
Schirrmacher V;Fournier P
本文重点关注溶瘤新城疫病毒（NDV）。本文总结了（i）该病毒作为抗癌和免疫刺激剂的特性，以及（ii）进一步利用该病毒作为载体来对抗癌症的方法。特别强调将病毒疗法与细胞疗法相结合以及改善肿瘤靶向。该综述将包括一些作者在新城疫病毒、双特异性抗体和细胞治疗方面的工作，作为多模式癌症治疗新视角的基石。广泛的抗肿瘤免疫再激活包括先天性和适应性、肿瘤抗原 (TA) 特异性和 TA 独立活性
This paper focuses on oncolytic Newcastle disease virus (NDV). This paper summarizes (i) the peculiarities of this virus as an anti-cancer and immune stimulatory agent and (ii) the approaches to further harness this virus as a vector to combat cancer. Special emphasis is given on combining virus therapy with cell therapy and on improving tumor targeting. The review will include some of the authors work on NDV, bi-specific antibodies, and cell therapy as building blocks for a new perspective of multimodal cancer therapy. The broad anti-tumor immune reactivation includes innate and adaptive, tumor antigen (TA) specific and TA independent activities