The time-course of the inflammatory response to major burn injury and its relation to organ failure and outcome
The time-course of the inflammatory response to major burn injury and its relation to organ failure and outcome
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DOI：
10.1016/j.burns.2018.09.001
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发表时间：
2019-03-01
期刊：
影响因子：
2.7
通讯作者：
Lipcsey, Miklos
中科院分区：
文献类型：
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作者：
Bergquist, Maria;Hastbacka, Johanna;Lipcsey, Miklos
烧伤引起主要炎症激活和细胞因子释放，然而，急性和亚急性炎症反应的时间分辨率尚未完全确定。为此，我们对烧伤后 0-21 天的 44 名成年患者血浆中的 20 种炎症介质进行了定量，并将这些介质的时间进程与烧伤总表面积 (TBSA) 百分比、临床参数、器官衰竭和结果相关联。在这些患者分析的细胞因子中，白细胞介素 6 (IL-6)、IL-8、IL-10 和单核细胞趋化蛋白 1 (MCP-1) 与烧伤后 24-48 小时的损伤大小相关。在我们的研究中，烧伤患者入院时和伤后 24-48 小时测量的 IL-10 浓度具有预后价值。然而，简单的人口统计数据，如年龄、TBSA 烧伤百分比、吸入性损伤及其组合、Baux 评分和改良 Baux 评分，在预测死亡方面优于大多数细胞因子（入院时的 IL-8 和 MCP1 水平除外）。 (C) 2018 Elsevier Ltd 和 ISBI。版权所有。
Burn injury causes major inflammatory activation and cytokine release, however, the temporal resolution of the acute and sub-acute inflammatory response has not yet been fully delineated. To this end, we have quantified 20 inflammatory mediators in plasma from 44 adult patients 0-21 days after burn injury and related the time course of these mediators to % total body surface area (TBSA) burned, clinical parameters, organ failure and outcome. Of the cytokines analyzed in these patients, interleukin 6 (IL-6), IL-8, IL-10 and monocyte chemoattractant protein 1 (MCP-1) correlated to the size of the injury at 24-48h after burn injury. In our study, the concentration of IL-10 had prognostic value in patients with burn injury both measured at admission and at 24-48h after injury. However, simple demographic data such as age, % burned TBSA, inhalation injury and their combination, the Baux score and modified Baux score, outperform most of the cytokines, with the exception of IL-8 and MCP1 levels on admission, in predicting death. (C) 2018 Elsevier Ltd and ISBI. All rights reserved.